Bone, inflammation, and inflammatory bowel disease.

Authors:
Manasi Agrawal
Manasi Agrawal
Maimonides Medical Center
Shitij Arora
Shitij Arora
Gandhi Medical College
India
Jianjun Li
Jianjun Li
Institute for Biological Sciences
Canada
Li Sun
Li Sun
Key Laboratory of Experimental Marine Biology
China
Adam F Steinlauf
Adam F Steinlauf
Mount Sinai School of Medicine
Associate Professor
Inflammatory Bowel Disease
New York, New York | United States
Jeffrey I Mechanick
Jeffrey I Mechanick
Mount Sinai School of Medicine
United States
Mone Zaidi
Mone Zaidi
Mount Sinai School of Medicine
United States

Curr Osteoporos Rep 2011 Dec;9(4):251-7

Department of Gastroenterology, Maimonides Medical Center, Brooklyn, NY 11201, USA.

Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.

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December 2011
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