Crit Rev Toxicol 2011 Oct;41(9):756-70
Centre of Expertise in Life Sciences, Zuyd University, Heerlen, The Netherlands.
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J Environ Pathol Toxicol Oncol 2001 ;20 Suppl 1:133-41
DuPont Haskell Laboratory, Newark, DE 19714-0050, USA.
The International Agency for Research on Cancer (IARC) recently published a monograph on the evaluation of carcinogenic risks to humans of exposure to crystalline and amorphous silica particles. The IARC Working Group concluded that crystalline silica, in the form of quartz or cristobalite, from occupational sources posed a carcinogenic risk to humans (Category 1). IARC also determined that amorphous silica particles were not classifiable as to its carcinogenicity to humans (Category 3). Read More
Mutat Res Genet Toxicol Environ Mutagen 2016 Jan 27;796:23-33. Epub 2015 Nov 27.
Département Toxicologie et Biométrologie, Institut National de Recherche et de Sécurité (INRS), Rue du Morvan, CS 60027, 54519 Vandoeuvre Les Nancy Cedex, France.
Crystalline silica particles and asbestos have both been classified as carcinogenic by the International Agency for Research on Cancer (IARC). However, because of the limited data available, amorphous silica was not classifiable. In vitro, the carcinogenic potential of natural crystalline and amorphous silica particles has been revealed by the Syrian Hamster Embryo (SHE) cell transformation assay. Read More
Part Fibre Toxicol 2018 05 21;15(1):23. Epub 2018 May 21.
Kirkland Consulting, Tadcaster, UK.
Human exposure to (certain forms of) crystalline silica (CS) potentially results in adverse effects on human health. Since 1997 IARC has classified CS as a Group 1 carcinogen , which was confirmed in a later review in 2012 . The genotoxic potential and mode of genotoxic action of CS was not conclusive in either of the IARC reviews, although a proposal for mode of actions was made in an extensive review of the genotoxicity of CS by Borm, Tran and Donaldson in 2011 . Read More
Crit Rev Toxicol 2013 Sep 18;43(8):632-60. Epub 2013 Jul 18.
Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405-0068, USA.
Silica or silicon dioxides (SiO₂) are naturally occurring substances that comprise the vast majority of the earth's crust. Because of their prevalence and commercial applications, they have been widely studied for their potential to induce pulmonary fibrosis and other disorders. Historically, the focus in the workplace has been on the development of inflammation and fibrotic lung disease, the basis for promulgating workplace standards to protect workers. Read More