Exp Gerontol 2011 Dec 28;46(12):970-8. Epub 2011 Aug 28.
Department of Physiology, University of Murcia, Spain.
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Exp Gerontol 2013 May 4;48(5):507-16. Epub 2013 Mar 4.
Department of Physiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain.
Adult (48-week-old) and senescent (72-week-old) individually-kept Nothobranchius korthausae were used as experimental subjects to characterise circadian system (CS) function and age-related changes in senescent fish. This species was specifically chosen because it has already shown potential for use as a model system in gerontological studies. The rest-activity rhythm (RAR) in fish can be easily monitored and used to characterise the state of the CS, and it has also been proposed as a reliable model to study sleep-like periods in fish. Read More
Chronobiol Int 2015 Apr 25;32(3):395-404. Epub 2014 Nov 25.
Faculty of Biology, Department of Physiology, University of Murcia , Murcia , Spain and.
Several studies have been performed to identify age-related changes in the circadian system (CS) but the impairment of the CS and its chronodisruption at the end of an organism life have not been studied in depth. Aging commonly affects the input pathways into the biological clock or restraints their processing, therefore simplifying the system output, the overt rhythms. The purpose of this work was to do a complete characterization of changes that occurs in the CS in the last stage of a vertebrate organism life and to develop tools able to detect in which moment of the last days of life is the animal, using an overt rhythm, the rest-activity rhythm (RAR). Read More
Aging Cell 2006 Jun;5(3):275-8
Scuola Normale Superiore, Pisa, Italy.
Temperature variations are known to modulate aging and life-history traits in poikilotherms as different as worms, flies and fish. In invertebrates, temperature affects lifespan by modulating the slope of age-dependent acceleration in death rate, which is thought to reflect the rate of age-related damage accumulation. Here, we studied the effects of temperature on aging kinetics, aging-related behavioural deficits, and age-associated histological markers of senescence in the short-lived fish Nothobranchius furzeri. Read More
Biogerontology 2015 Feb 15;16(1):63-9. Epub 2014 Oct 15.
Biology of Aging, Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany.
Nothobranchius is a genus of annual fish broadly distributed in South-Eastern Africa and found into temporary ponds generated during the rain seasons and their lifespan is limited by the duration of their habitats. Here we compared two Nothobranchius species from radically different environments: N. furzeri and N. Read More