The efficacy of a topical gel with triester glycerol oxide in denture-related mucosal injuries.

Gerodontology 2012 Jun 24;29(2):e715-20. Epub 2011 Aug 24.

Department of Prosthodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.

Objective: The efficacy of a topical gel with triester glycerol oxide for treating ulcerations related to new complete dentures was studied and compared with a placebo gel.

Materials And Methods: Fifty edentulous patients were enrolled in this double-blind clinical study. All subjects received new maxillary and mandibular complete dentures and were recalled 1, 3 and 7 days after denture placement. Twenty-five subjects received topical gel with triester glycerol oxide (TGO), and 25 subjects received topical gel without TGO. At each visit, pain and discomfort with the new dentures was assessed, and at the last visit, healing of ulcerations was also graded by a clinician. Subjects also graded the gel's taste, smell and ease of use.

Results: Specifically, there was no statistically significant difference in ulcer healing (p > 0.05), ratings of smell, taste and ease of use (p > 0.05) or pain and discomfort scores (p > 0.05). However, within-group differences were observed in pain and discomfort scores between follow-up sessions (p = 0.01 for all comparisons).

Conclusion: Clinically, TGO gel is not effective in the treatment of mucosal injuries occurring following placement of complete dentures.

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http://dx.doi.org/10.1111/j.1741-2358.2011.00549.xDOI Listing
June 2012
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References

(Supplied by CrossRef)
Frequency and location of traumatic ulcerations following placement of complete dentures
Kivovics et al.
Int J Prosthodont 2007
Oral mucosal lesions in denture wearers
Jainkittivong et al.
Gerodontology 2010
Denture-induced fibrous inflammatory hyperplasia: a retrospective study in a school of dentistry
Coelho et al.
Int J Prosthodont 2000

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