J Allergy Clin Immunol 2011 Dec 25;128(6):1369-71. Epub 2011 Aug 25.
Atherosclerosis 2021 Apr 24;326:1-10. Epub 2021 Apr 24.
Department of Clinical Sciences, Lund University, Skåne University Hospital, 20502, Malmö, Sweden. Electronic address:
Background And Aims: The relationship between inflammation and lipid metabolism is complex and bidirectional. Lymphocyte-driven inflammation has been shown to modulate both atherosclerotic plaque development and cholesterol levels, but the mechanisms are incompletely understood.Methods: The cardiometabolic effects of IL-2Rβγ signalling in atherosclerotic Apoe mice were investigated by treatment with an agonistic IL-2Rβγ-targeting IL-2/anti-IL-2 complex or a monoclonal anti-CD122 (IL-2Rβ) blocking antibody. Read More
Antioxidants (Basel) 2021 Apr 8;10(4). Epub 2021 Apr 8.
Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.
Pancreatic stellate cells (PSC) play a major role in the formation of fibrotic tissue in pancreatic tumors. On its side, melatonin is a putative therapeutic agent for pancreatic cancer and inflammation. In this work, the actions of melatonin on PSC subjected to hypoxia were evaluated. Read More
J Gene Med 2021 Apr 26:e3349. Epub 2021 Apr 26.
Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Background: Propofol (PPF) plays a protective role in ischemia-reperfusion (I/R) in multiple organs, including renal ischemia-reperfusion injury (RIRI). This work is intended to investigate the underlying mechanisms by which PPF exerts its protective functions in RIRI.Methods: BALB/c mice were employed for the construction of RIRI animal model. Read More
Arch Biochem Biophys 2021 Apr 20;704:108875. Epub 2021 Apr 20.
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Analítica y Fisicoquímica, Cátedra de Química General e Inorgánica, Argentina; Universidad de Buenos Aires, CONICET, Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Argentina. Electronic address:
Previous reports indicate that the central nervous system (CNS) is a target of air pollution, causing tissue damage and functional alterations. Oxidative stress and neuroinflammation have been pointed out as possible mechanisms mediating these effects. The aim of this work was to study the chronic effects of urban air pollution on mice brain cortex, focusing on oxidative stress markers, and mitochondrial function. Read More
Nat Commun 2021 04 22;12(1):2368. Epub 2021 Apr 22.
Department of Pediatrics, Yale University School of Medicine New Haven, New Haven, CT, USA.
Endothelial cells play a key role in the regulation of disease. Defective regulation of endothelial cell homeostasis may cause mesenchymal activation of other endothelial cells or neighboring cell types, and in both cases contributes to organ fibrosis. Regulatory control of endothelial cell homeostasis is not well studied. Read More