Biochim Biophys Acta 2011 Dec 10;1816(2):219-31. Epub 2011 Aug 10.
Centro de Investigação de Patobiologia Molecular CIPM, Instituto Português de Oncologia de Lisboa Francisco Gentil, Rua Prof. Lima Basto 1099-023 Lisboa, Portugal.
In contrast to the majority of sporadic colorectal cancer which predominantly occur in the distal colon, most mismatch repair deficient tumours arise at the proximal side. At present, these regional preferences have not been explained properly. Recently, we have screened colorectal tumours for mutations in Wnt-related genes focusing specifically on colorectal location. Combining this analysis with published data, we propose a mechanism underlying the side-related preferences of colorectal cancers, based on the specific acquired genetic defects in β-catenin signalling.