Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.

Nat Genet 2011 Aug 7;43(9):828-9. Epub 2011 Aug 7.

Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.

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http://www.nature.com/articles/ng.903
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163746PMC
August 2011
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