What could predict effectiveness of Botulinum Toxin to treat drooling: a search for evidence of discriminatory factors on the level of body functions or structures.

Authors:
Corrie E Erasmus
Corrie E Erasmus
Radboud University Nijmegen Medical Centre
Netherlands
Peter H Jongerius
Peter H Jongerius
University Medical Center
Tuscaloosa | United States

Eur J Paediatr Neurol 2012 Mar 23;16(2):126-31. Epub 2011 Jul 23.

Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behavior, Department of Paediatric Neurology, Nijmegen, The Netherlands.

Background: The treatment of drooling is important to families that experience the daily impact and research to elucidate clinical factors that play a role in the outcome of drooling treatment should be encouraged.

Aim: To define clinical factors that influence therapy outcome of submandibular Botulinum Toxin (BoNT-A) injections for drooling.

Methods: Prospectively collected data of 128 children with cerebral palsy were evaluated; 80 spastic and 48 dyskinetic movement disorder, mostly Gross Motor Function Classification System III and higher; over 70% had an IQ <70. In addition, 23 fully ambulant children with exclusively intellectual disability were treated for drooling by ultrasound-guided injections of BoNT-A into the submandibular glands. Salivary flow rates and drooling quotients were measured at baseline and at 8 weeks after injection. Extensive information about the oral motor performance was gathered. Successful clinical response was defined as a 50% reduction of the baseline Drooling Quotient; 85 children were responsive to BoNT-A and 66 children unresponsive.

Results: Five nominated clinical factors that possibly could influence saliva reduction (head position, lip seal, voluntary control over the tongue, control of voluntary movement functions, and mental age) did not influence the responsiveness to BoNT-A.

Interpretation: Other variables need to be considered to predict the outcome of BoNT-A treatment. This article describes the first attempt to reveal the contribution of body functions and structures to the outcome of BoNT-A submandibular injections.

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10903798110012
Publisher Site
http://dx.doi.org/10.1016/j.ejpn.2011.06.002DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
March 2012
41 Reads

Publication Analysis

Top Keywords

clinical factors
8
botulinum toxin
8
outcome submandibular
4
therapy outcome
4
influence therapy
4
submandibular botulinum
4
toxin bont-a
4
injections droolingmethods
4
bont-a injections
4
factors influence
4
droolingmethods prospectively
4
treatment encouragedaim
4
play role
4
factors play
4
elucidate clinical
4
role outcome
4
outcome drooling
4
prospectively collected
4
drooling treatment
4
define clinical
4

Similar Publications