Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

Authors:
Ali Amin Olama, PhD
Ali Amin Olama, PhD
University Of Cambridge
Dr.
Cambridge | United Kingdom
Zsofia Kote-Jarai Ali Amin Al Olama Graham G Giles Gianluca Severi Johanna Schleutker Maren Weischer Daniele Campa Elio Riboli Tim Key Henrik Gronberg David J Hunter Peter Kraft Michael J Thun Sue Ingles Stephen Chanock Demetrius Albanes Richard B Hayes David E Neal Freddie C Hamdy Jenny L Donovan Paul Pharoah Fredrick Schumacher Brian E Henderson Janet L Stanford Elaine A Ostrander Karina Dalsgaard Sorensen Thilo Dörk Gerald Andriole Joanne L Dickinson Cezary Cybulski Jan Lubinski Amanda Spurdle Judith A Clements Suzanne Chambers Joanne Aitken R A Frank Gardiner Stephen N Thibodeau Dan Schaid Esther M John Christiane Maier Walther Vogel Kathleen A Cooney Jong Y Park Lisa Cannon-Albright Hermann Brenner Tomonori Habuchi Hong-Wei Zhang Yong-Jie Lu Radka Kaneva Ken Muir Sara Benlloch Daniel A Leongamornlert Edward J Saunders Malgorzata Tymrakiewicz Nadiya Mahmud Michelle Guy Lynne T O'Brien Rosemary A Wilkinson Amanda L Hall Emma J Sawyer Tokhir Dadaev Jonathan Morrison David P Dearnaley Alan Horwich Robert A Huddart Vincent S Khoo Christopher C Parker Nicholas Van As Christopher J Woodhouse Alan Thompson Tim Christmas Chris Ogden Colin S Cooper Aritaya Lophatonanon Melissa C Southey John L Hopper Dallas R English Tiina Wahlfors Teuvo L J Tammela Peter Klarskov Børge G Nordestgaard M Andreas Røder Anne Tybjærg-Hansen Stig E Bojesen Ruth Travis Federico Canzian Rudolf Kaaks Fredrik Wiklund Markus Aly Sara Lindstrom W Ryan Diver Susan Gapstur Mariana C Stern Roman Corral Jarmo Virtamo Angela Cox Christopher A Haiman Loic Le Marchand Liesel Fitzgerald Suzanne Kolb Erika M Kwon Danielle M Karyadi Torben Falck Orntoft Michael Borre Andreas Meyer Jürgen Serth Meredith Yeager Sonja I Berndt James R Marthick Briony Patterson Dominika Wokolorczyk Jyotsna Batra Felicity Lose Shannon K McDonnell Amit D Joshi Ahva Shahabi Antje E Rinckleb Ana Ray Thomas A Sellers Hui-Yi Lin Robert A Stephenson James Farnham Heiko Muller Dietrich Rothenbacher Norihiko Tsuchiya Shintaro Narita Guang-Wen Cao Chavdar Slavov Vanio Mitev Douglas F Easton Rosalind A Eeles

Nat Genet 2011 Jul 10;43(8):785-91. Epub 2011 Jul 10.

The Institute of Cancer Research, Sutton, Surrey, UK.

Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ∼25% of the familial risk in this disease, have now been identified.

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http://dx.doi.org/10.1038/ng.882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396006PMC
July 2011
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