Flavans from Iris tenuifolia and their effects on β-amyloid aggregation and neural stem cells proliferation in vitro.

Authors:
Hui Wang
Hui Wang
State Key Laboratory Breeding Base of Dao-di Herbs
China
Mei Han
Mei Han
College of Chemistry
China
Yang Lu
Yang Lu
City University of Hong Kong
China

Bioorg Med Chem Lett 2011 Aug 17;21(15):4400-3. Epub 2011 Jun 17.

Key Laboratory for Cell Proliferation and Regulation Biology, Beijing Key Laboratory of Gene Engineering Drugs and Biological Technology, College of Life Sciences, Beijing Normal University, Beijing, PR China.

Two new flavans (1, 2) and a new flavanone (3), together with three known compounds (4-6), were isolated from the roots of Iris tenuifolia. Their structures were elucidated by means of spectroscopic methods including 1D and 2D NMR techniques and mass spectrometry. Compounds 1, 4, and 6 were further confirmed by single-crystal X-ray diffraction analysis. Biological evaluation showed that compounds 1 and 4 were positive in inhibiting β-amyloid (Aβ) aggregation and promoting neural stem cells (NSCs) proliferation, respectively.

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http://dx.doi.org/10.1016/j.bmcl.2011.06.039DOI Listing

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August 2011
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