Cell Cycle 2011 Jul 15;10(14):2254. Epub 2011 Jul 15.
Int J Infect Dis 2021 Mar 16. Epub 2021 Mar 16.
Department of Clinical Epidemiology, Office of Clinical Epidemiology, Analytics, and Knowledge, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address:
Objective: We assessed the performance of influenza-like illness (ILI) case definitions by the Centers for Disease Control and Prevention (CDC), European Centers for Disease Control and Prevention (ECDC), and World Health Organization (WHO) in the tropics where the seasonal patterns of respiratory viruses in acute upper respiratory tract infections (AURTIs) are ill defined.Methods: Clinical data and samples for respiratory multiplex PCR test were collected from 717 consecutive patients attending for uncomplicated AURTI at a busy emergency department in Singapore, 2016-2018.Results: Influenza (20. Read More
Zoolog Sci 2021 Feb;38(1):82-89
Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan,
Many insects show daily and circadian changes in morphology and physiology in their compound eye. In this study, we investigated whether the compound eye had an intrinsic circadian rhythm in the cricket . We found that clock genes (), (), (), and () were rhythmically expressed in the compound eye under 12-h light/12-h dark cycles (LD 12:12) and constant darkness (DD) at a constant temperature. Read More
Front Physiol 2021 2;12:622545. Epub 2021 Feb 2.
Institute of Neuro- and Behavioral Biology, Westfälische Wilhelms-Universität Münster, Münster, Germany.
Circadian clocks are cell-autonomous endogenous oscillators, generated and maintained by self-sustained 24-h rhythms of clock gene expression. In the fruit fly , these daily rhythms of gene expression regulate the activity of approximately 150 clock neurons in the fly brain, which are responsible for driving the daily rest/activity cycles of these insects. Despite their endogenous character, circadian clocks communicate with the environment in order to synchronize their self-sustained molecular oscillations and neuronal activity rhythms (internal time) with the daily changes of light and temperature dictated by the Earth's rotation around its axis (external time). Read More
BMC Genomics 2021 Jan 28;22(1):84. Epub 2021 Jan 28.
Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, 13125, Berlin, Germany.
Background: Co-localized combinations of histone modifications ("chromatin states") have been shown to correlate with promoter and enhancer activity. Changes in chromatin states over multiple time points ("chromatin state trajectories") have previously been analyzed at promoter and enhancers separately. With the advent of time series Hi-C data it is now possible to connect promoters and enhancers and to analyze chromatin state trajectories at promoter-enhancer pairs. Read More
J Biol Rhythms 2021 Feb 11;36(1):84-96. Epub 2021 Jan 11.
Howard Hughes Medical Institute, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
The circadian field has come a long way since I started as a postdoctoral fellow ~30 years ago. At the time, the only known animal clock gene was , so I had the privilege of witnessing, and participating in, the molecular revolution that took us from the discovery of the circadian clock mechanism to the identification of pathways that link clocks to behavior and physiology. This lecture highlights my role and perspective in these developments, and also demonstrates how the successful use of Drosophila for studies of circadian rhythms inspired us to develop a fly model for sleep. Read More