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Drug Test Anal 2022 Aug 9. Epub 2022 Aug 9.

ULB, Faculty of Pharmacy, RD3, Pharmacognosy, Bioanalysis and Drug Discovery Unit, Bld Triomphe, Campus Plaine, CP 205/6, Brussels, Belgium.

Herbal products for smoking containing cannabidiol (CBD) are available as "low-tetrahydrocannabinol cannabis products" in most EU countries. In Belgium, Δ9-tetrahydrocannabinol (THC) content of these products must be less than 0.2 % w/w, which is also the limit for agricultural hemp. Read More

Emerg Med J 2022 Aug 9. Epub 2022 Aug 9.

Anaesthesiology, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands.

Objective: Risk stratification is increasingly based on Early Warning Score (EWS)-based models, instead of clinical judgement. However, it is unknown how risk-stratification models and EWS perform as compared with the clinical judgement of treating acute healthcare providers. Therefore, we performed a systematic review of all available literature evaluating clinical judgement of healthcare providers to the use of risk-stratification models in predicting patients' clinical outcome. Read More

Respir Care 2022 Aug 9. Epub 2022 Aug 9.

Department of Integrative Medicine, Universidade Federal do Paraná, Curitiba, Brazil.

Background: COVID-19 pneumonia has been responsible for many ICU patients' admissions with hypoxemic respiratory failure, and oxygen therapy is one of the pillars of its treatment. The current pandemic scenario has limited the availability of ICU beds and access to invasive ventilation equipment. High-flow nasal cannula (HFNC) can reduce the need for orotracheal intubation compared with conventional oxygen therapy, providing better results than noninvasive respiratory support. Read More

Harmful Algae 2022 Aug 25;117:102273. Epub 2022 Jun 25.

Nagaoka University of Technology, 1603-1, Kamitomioka, Nagaoka-shi, 940-2188, Niigata, Japan.

Machine learning, Deep learning, and water quality data have been used in recent years to predict the outbreak of harmful algae, especially Microcystis, and analyze outbreak causes. However, for various reasons, water quality data are often High-Dimension, Low-Sample- Size (HDLSS), meaning the sample size is lower than the number of dimensions. Moreover, imbalance problems may arise due to bias in the occurrence frequency of Microcystis. Read More

Life Sci Alliance 2022 Dec 9;5(12). Epub 2022 Aug 9.

Institute for the Advanced Study of Human Biology, Kyoto University Institute for Advanced Study, Kyoto University, Kyoto, Japan

Single-cell RNA sequencing (scRNA-seq) can determine gene expression in numerous individual cells simultaneously, promoting progress in the biomedical sciences. However, scRNA-seq data are high-dimensional with substantial technical noise, including dropouts. During analysis of scRNA-seq data, such noise engenders a statistical problem known as the curse of dimensionality (COD). Read More