The early repolarization pattern in the general population: clinical correlates and heritability.

Authors:
Peter A Noseworthy
Peter A Noseworthy
Mayo Clinic
United States
Jani T Tikkanen
Jani T Tikkanen
Medical Research Center Oulu
Kimmo Porthan
Kimmo Porthan
Helsinki University Central Hospital
Finland
Lasse Oikarinen
Lasse Oikarinen
Helsinki University Central Hospital
Kennet Harald
Kennet Harald
National Institute for Health and Welfare
Finland
Gina M Peloso
Gina M Peloso
Massachusetts General Hospital
United States
Faisal M Merchant
Faisal M Merchant
Emory University School of Medicine
United States

J Am Coll Cardiol 2011 May;57(22):2284-9

Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.

Objectives: This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based cohorts.

Background: There is growing recognition that ERP is associated with adverse outcomes.

Methods: Participants of the Framingham Heart Study (FHS) (N = 3,995) and the Health 2000 Survey (H2K) (N = 5,489) were included. ERP was defined as a J-point elevation ≥0.1 mV in ≥2 leads in either the inferior (II, III, aVF) or lateral (I, aVL, V(4-6)) territory or both. We tested the association between clinical characteristics and ERP, and estimated sibling recurrence risk.

Results: ERP was present in 243 of 3,955 (6.1%) of FHS and 180 of 5,489 (3.3%) of H2K subjects. Male sex, younger age, lower systolic blood pressure, higher Sokolow-Lyon index, and lower Cornell voltage were independently associated with the presence of ERP. In the FHS sample, siblings of individuals with ERP had an ERP prevalence of 11.6% (recurrence risk ratio of 1.89). Siblings of individuals with ERP had an increased unadjusted odds of ERP (odds ratio: 2.22, 95% confidence interval: 1.01 to 4.85, p = 0.047).

Conclusions: ERP has strong association with clinical factors and has evidence for a heritable basis in the general population. Further assessment of the genetic determinants of ERP is warranted.

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Source
http://dx.doi.org/10.1016/j.jacc.2011.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183435PMC
May 2011
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