Balancing forces: architectural control of mechanotransduction.

Authors:
Christopher C DuFort
Christopher C DuFort
University of California
United States
Matthew J Paszek
Matthew J Paszek
University of Pennsylvania
United States
Valerie M Weaver
Valerie M Weaver
University of Pennsylvania
United States

Nat Rev Mol Cell Biol 2011 May;12(5):308-19

Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco (UCSF), CA, USA.

All cells exist within the context of a three-dimensional microenvironment in which they are exposed to mechanical and physical cues. These cues can be disrupted through perturbations to mechanotransduction, from the nanoscale-level to the tissue-level, which compromises tensional homeostasis to promote pathologies such as cardiovascular disease and cancer. The mechanisms of such perturbations suggest that a complex interplay exists between the extracellular microenvironment and cellular function. Furthermore, sustained disruptions in tensional homeostasis can be caused by alterations in the extracellular matrix, allowing it to serve as a mechanically based memory-storage device that can perpetuate a disease or restore normal tissue behaviour.

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http://dx.doi.org/10.1038/nrm3112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564968PMC

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May 2011
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References

(Supplied by CrossRef)
Article in Endocrinol.
Sniadecki N. J. et al.
Endocrinol. 2010
Article in Trends. Cell Biol.
Monshausen G. B. et al.
Trends. Cell Biol. 2009
Article in Cell Tissue Res.
van der Flier A. et al.
Cell Tissue Res. 2001
Article in J. Cell Biol.
Zaidel-Bar R. et al.
J. Cell Biol. 2009
Article in Nature Rev. Mol. Cell Biol.
Jaalouk D. E. et al.
Nature Rev. Mol. Cell Biol. 2009
Article in Physiol. Rev.
Hamill O. P. et al.
Physiol. Rev. 2001
Article in FASEB J.
Ingber D. E. et al.
FASEB J. 2006
Article in J. Biol. Chem.
Katsumi A. et al.
J. Biol. Chem. 2004
Article in Nature Rev. Mol. Cell Biol.
Vogel V. et al.
Nature Rev. Mol. Cell Biol. 2006
Article in Nature
Lansman J. B. et al.
Nature 1987
Article in Nature
Tzima E. et al.
Nature 2005

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