Minimal absent words in prokaryotic and eukaryotic genomes.

PLoS One 2011 Jan 31;6(1):e16065. Epub 2011 Jan 31.

Signal Processing Laboratory, IEETA, University of Aveiro, Aveiro, Portugal.

Minimal absent words have been computed in genomes of organisms from all domains of life. Here, we explore different sets of minimal absent words in the genomes of 22 organisms (one archaeota, thirteen bacteria and eight eukaryotes). We investigate if the mutational biases that may explain the deficit of the shortest absent words in vertebrates are also pervasive in other absent words, namely in minimal absent words, as well as to other organisms. We find that the compositional biases observed for the shortest absent words in vertebrates are not uniform throughout different sets of minimal absent words. We further investigate the hypothesis of the inheritance of minimal absent words through common ancestry from the similarity in dinucleotide relative abundances of different sets of minimal absent words, and find that this inheritance may be exclusive to vertebrates.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016065PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031530PMC
January 2011
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