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J Am Coll Cardiol 2022 May;79(20):2001-2017

Philippine Nuclear Research Institute, Quezon City, Philippines.

Background: The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown.

Objectives: The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnostic services, and perceived psychological stress to health care providers worldwide.

Methods: The International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular diagnostic care at the pandemic's onset and 1 year later. Read More

Genes Dev 2022 May 19. Epub 2022 May 19.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Although splicing is a major driver of RNA nuclear export, many intronless RNAs are efficiently exported to the cytoplasm through poorly characterized mechanisms. For example, GC-rich sequences promote nuclear export in a splicing-independent manner, but how GC content is recognized and coupled to nuclear export is unknown. Here, we developed a genome-wide screening strategy to investigate the mechanism of export of , an intronless cytoplasmic long noncoding RNA (lncRNA). Read More

J Ethnopharmacol 2022 May 16:115391. Epub 2022 May 16.

Centre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. Electronic address:

Ethnopharmacological Relevance: Gynura procumbens (Lour.) Merr. is a herbaceous plant that grows in Malaysia and other parts of Southeast Asia. Read More

J Ethnopharmacol 2022 May 16:115389. Epub 2022 May 16.

Department of Physics, Chemistry and Material Science, Faculty of Agriculture, Engineering and Natural Sciences, University of Namibia, Private Bag, 13301, Windhoek, Namibia. Electronic address:

Ethnopharmacological Relevance: Eight indigenous medicinal plants which are used traditionally for the treatment of tuberculosis (TB), malaria, and associated symptoms, were selected for this study.

Aim Of Study: The aim of this study was to evaluate the antiplasmodial and antimycobacterial activities of the organic and aqueous crude extracts of different plant parts, by comparing the activities of subfractions (lead-like enhanced [LLE] extracts and methanol fractions) prepared from the bioactive crude extracts.

Materials & Methods: Crude aqueous and organic extracts were prepared for 25 different plant parts obtained from eight plant species. Read More

Biochim Biophys Acta Gen Subj 2022 May 16:130171. Epub 2022 May 16.

Department of Immunology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

Reactive oxygen species (ROS) acts as a second messenger to trigger biological responses in low concentrations, while it is implicated to be toxic to biomolecules in high concentrations. Mild inhibition of respiratory chain Complex I by metformin at physiologically relevant concentrations stimulates production of low-level mitochondrial ROS. The ROS seems to induce anti-oxidative stress response via activation of nuclear factor erythroid 2- related factor 2 (Nrf2) and glutathione peroxidase (GPx), which results in not only elimination of ROS but also activation of cellular responses including resistance to apoptosis, metabolic changes, cell proliferation, senescence prevention, lifespan extension, and immune T cell activation against cancers, regardless of its effect controlling blood glucose level and T2DM. Read More