Trials 2011 Mar 2;12:62. Epub 2011 Mar 2.
Dept, of Clinical Neurosciences, University of Cambridge, UK.
Tissue Cell 2021 Feb 26;71:101518. Epub 2021 Feb 26.
Chengdu Research Base of Giant Panda Breeding, Chengdu, Sichuan Province, 610000, China; Sichuan Key Laboratory of Conservation Biology for Endangered Wildlife, Chengdu, Sichuan Province, 610000, China. Electronic address:
Umbilical cord-derived mesenchymal stem cells (UC-MSCs) constitute a class of cells with significant self-renewal and multilineage differentiation properties and have great potential for therapeutic applications and the genetic conservation of endangered animals. In this study, we successfully isolated and cultured UC-MSCs from the blood vessels of giant panda umbilical cord (UC). The cells were arranged in a vortex or cluster pattern and exhibited a normal karyotype, showing the morphological characteristics of fibroblasts. Read More
Biomaterials 2021 Feb 15;271:120722. Epub 2021 Feb 15.
Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Department of Orthopedic Surgery of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China; China Orthopaedic Regenerative Medicine (CORMed), Hangzhou, China. Electronic address:
Tendon injuries are the leading cause of chronic debilitation to patients. Tendon stem/progenitor cells (TSPCs) are potential seed cells for tendon tissue engineering and regeneration, but TSPCs are prone to lose their distinct phenotype in vitro and specific differentiation into the tenocyte lineage is challenging. Utilizing small molecules in an ex vivo culture system may be a promising solution and can significantly improve the therapeutic applications of these cells. Read More
Stem Cell Res 2021 Feb 26;53:102272. Epub 2021 Feb 26.
Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Singapore. Electronic address:
Mesenchymal stem cells (MSCs) are of great clinical interest as a form of allogenic therapy due to their excellent regenerative and immunomodulatory effects for various therapeutic indications. Stirred suspension bioreactors using microcarriers (MC) have been used for large-scale production of MSCs compared to planar cultivation systems. Previously, we have demonstrated that expansion of MSCs in MC-spinner cultures improved chondrogenic, osteogenic, and cell migration potentials as compared to monolayer-static cultures. Read More
Genomics Proteomics Bioinformatics 2021 Mar 3. Epub 2021 Mar 3.
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore; The State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China. Electronic address:
Chromatin modification contributes to pluripotency maintenance in embryonic stem cells (ESCs). However, the related mechanisms remain obscure. Here, we show that Npac, a "reader" of histone H3 lysine 36 trimethylation (H3K36me3), is required to maintain mouse ESC (mESC) pluripotency since knockdown of Npac causes mESC differentiation. Read More
Prog Retin Eye Res 2021 Mar 3:100956. Epub 2021 Mar 3.
Cornea Division, Stein Eye Institute, University of California, Los Angeles, CA, 90095, USA. Electronic address:
The corneal epithelium is continuously renewed by limbal stem/progenitor cells (LSCs), a cell population harbored in a highly regulated niche located at the limbus. Dysfunction and/or loss of LSCs and their niche cause limbal stem cell deficiency (LSCD), a disease that is marked by invasion of conjunctival epithelium into the cornea and results in failure of epithelial wound healing. Corneal opacity, pain, loss of vision, and blindness are the consequences of LSCD. Read More