Search Our Scientific Publications & Authors

Sci Rep 2021 Apr 9;11(1):7832. Epub 2021 Apr 9.

Neurotoxin Research Program, Department of Biological Sciences, Allergan (an AbbVie Company) R&D, 2525 Dupont Dr., RD3-3B, Irvine, CA, 92612, USA.

Clostridium botulinum neurotoxin serotype A (BoNT/A) is a potent neurotoxin that serves as an effective therapeutic for several neuromuscular disorders via induction of temporary muscular paralysis. Specific binding and internalization of BoNT/A into neuronal cells is mediated by its binding domain (H/A), which binds to gangliosides, including GT1b, and protein cell surface receptors, including SV2. Previously, recombinant H/A was also shown to bind to FGFR3. Read More

Int J Mol Sci 2021 Mar 29;22(7). Epub 2021 Mar 29.

Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou 510631, China.

FCS-like zinc finger family proteins (FLZs), a class of plant-specific scaffold of SnRK1 complex, are involved in the regulation of various aspects of plant growth and stress responses. Most information of family genes was obtained from the studies in , whereas little is known about the potential functions of in crop plants. In this study, 37 maize () genes were identified to be asymmetrically distributed on 10 chromosomes and can be divided into three subfamilies. Read More

Front Syst Neurosci 2021 10;15:596221. Epub 2021 Mar 10.

Department of Neurology, Beijing Geriatric Hospital, Beijing, China.

This case-control study is aimed to investigate the correlation of altered functional connectivity (FC) in cerebellum with cognitive impairment in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). The morphometric and resting-state FC MRI analysis including 46 participants with AD, 32 with aMCI and 42 age-matched normal controls (NCs) were conducted. We compared the cerebellar gray matter volume and cerebellar FC with cerebral cortical regions among three groups. Read More

J Biol Chem 2021 Mar 18:100565. Epub 2021 Mar 18.

Department of Chemistry, Biochemistry Division, Johannes Gutenberg-University, Mainz, Germany; Centre for Biomolecular Magnetic Resonance (BMRZ), Goethe University, Frankfurt, Germany; current address: Faculty of Chemistry and Earth Sciences, Institute of Organic and Macromolecular Chemistry, Friedrich-Schiller-University, Jena, Germany; Cluster of Excellence 'Balance of the Microverse', Friedrich-Schiller-University, Jena, Germany. Electronic address:

Rhodesain is the lysosomal cathepsin L-like cysteine protease of T. brucei rhodesiense, the causative agent of Human African Trypanosomiasis. The enzyme is essential for the proliferation and pathogenicity of the parasite as well as its ability to overcome the blood-brain barrier of the host. Read More

J Phys Chem A 2021 Apr 16;125(12):2425-2435. Epub 2021 Mar 16.

Micron School for Materials Science and Engineering, Boise State University, Boise, Idaho 83725, United States.

Femtosecond laser pulses can produce oscillatory signals in transient-absorption spectroscopy measurements. The quantum beats are often studied using femtosecond coherence spectra (FCS), the Fourier domain amplitude, and phase profiles at individual oscillation frequencies. In principle, one can identify the mechanism that gives rise to each quantum-beat signal by comparing its measured FCS to those arising from microscopic models. Read More