Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae.

Authors:
Zhenhua Guo Aleksandra B Adomas Erin D Jackson Hong Qin Jeffrey P Townsend

FEMS Yeast Res 2011 Jun 1;11(4):345-55. Epub 2011 Mar 1.

Germplasm Bank of Wild Species, Kunming Institute of Botany, Chinese Academy of Sciences, China.

We investigated the mechanism underlying the natural variation in longevity within natural populations using the model budding yeast, Saccharomyces cerevisiae. We analyzed whole-genome gene expression in four progeny of a natural S. cerevisiae strain that display differential replicative aging. Genes with different expression levels in short- and long-lived strains were classified disproportionately into metabolism, transport, development, transcription or cell cycle, and organelle organization (mitochondrial, chromosomal, and cytoskeletal). With several independent validating experiments, we detected 15 genes with consistent differential expression levels between the long- and the short-lived progeny. Among those 15, SIR2, HSP30, and TIM17 were upregulated in long-lived strains, which is consistent with the known effects of gene silencing, stress response, and mitochondrial function on aging. The link between SIR2 and yeast natural life span variation offers some intriguing ties to the allelic association of the human homolog SIRT1 to visceral obesity and metabolic response to lifestyle intervention.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1567-1364.2011.00723.xDOI Listing
June 2011

Publication Analysis

Top Keywords

replicative aging
8
saccharomyces cerevisiae
8
yeast saccharomyces
8
budding yeast
8
long-lived strains
8
expression levels
8
natural
5
lifestyle intervention
4
classified disproportionately
4
tim17 upregulated
4
strains classified
4
upregulated long-lived
4
strains consistent
4
short- long-lived
4
consistent effects
4
levels short-
4
disproportionately metabolism
4
effects gene
4
genes expression
4
aging genes
4

Keyword Occurance

Similar Publications

Outcomes Associated With Translating Evidence-Based Research Into Practice: The Physical Activity for Lifelong Success Program.

Authors:
Erin E Eggert Will Palmer Lourdes I Shanjani Kimberlee Gretebeck Jane E Mahoney

J Phys Act Health 2023 Sep 26:1-13. Epub 2023 Sep 26.

Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Background: Few programs assess for outcomes once translated into practice. The Physical Activity for Lifelong Success program was developed as a center-based public health intervention and shown to improve walking speed and distance among older adults with type 2 diabetes. We adapted the program for community-based delivery by lay leaders to physically inactive older adults. Read More

View Article and Full-Text PDF
September 2023
Similar Publications

RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway.

Authors:
Yanqi Mai Tong Lin Lili Zhang Wanqi Yang Sitong Liu Minghui Wang Peiqing Liu Zhuoming Li Wenwei Luo

Can J Physiol Pharmacol 2023 Sep 25. Epub 2023 Sep 25.

Sun Yat-Sen University, 26469, School of pharmaceutical sciences, Guangzhou, China.

RAD54B belongs to the SNF2/SWI2 superfamily, participating in homologous recombination repair. DNA damage is the central driver of aging, but there is no direct evidence of an association between RAD54B and vascular aging. The present study sought to investigate the role and mechanisms of RAD54B in endothelial senescence. Read More

View Article and Full-Text PDF
September 2023
Similar Publications

Aging-disturbed FUS Phase Transition Impairs Hematopoietic Stem Cell by Altering Chromatin Structure.

Authors:
Baixue Tang Xinming Wang Hanqing He Ruiqing Chen Guofeng Qiao Yang Yang Zihan Xu Longteng Wang Qiongye Dong Jia Yu Michael Zhang Minglei Shi Jianwei Wang

Blood 2023 Sep 25. Epub 2023 Sep 25.

Tsinghua University, Beijing, China.

Aged hematopoietic stem cells (HSCs) exhibit compromised reconstitution capacity. While, the molecular mechanisms behind this phenomenon are not fully understood. In this study, we observed that the expression of FUS is increased in aged HSCs and enforced FUS recapitulates the phenotype of aged HSCs through RGG-mediated aberrant FUS phase transition. Read More

View Article and Full-Text PDF
September 2023
Similar Publications

Accelerated telomere shortening in adrenal zona reticularis in patients with prolonged critical illness.

Authors:
Keisuke Nonaka Kaiyo Takubo Junko Aida Yoriko Watai Akiko Komatsu Fujiya Gomi Yuuki Shichi Yuto Yamazaki Toshiyuki Ishiwata Hironobu Sasano Tomio Arai

Front Endocrinol (Lausanne) 2023 4;14:1244553. Epub 2023 Sep 4.

Department of Pathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.

Background: The number of patients with prolonged critical illness (PCI) has been increasing in many countries, and the adrenal gland plays an important role in maintaining homeostasis during PCI. Chronic disease burden is reportedly associated with shorter telomere lengths in human tissues. Telomere shortening in human somatic cells is largely dependent on cell divisions, and critically short telomeres lead to cellular dysfunction and aging. Read More

View Article and Full-Text PDF
September 2023
Similar Publications

Construction of healthy aging index from two different datasets.

Authors:
Madara Miķelsone Ieva Reine Signe Tomsone Helgi Guðmundsson Andrejs Ivanovs Halldór S Guðmundsson

Front Public Health 2023 6;11:1231779. Epub 2023 Sep 6.

Faculty of Social Work, University of Iceland, Reykjavik, Iceland.

Introduction: The aging population presents both unique challenges and opportunities for societies around the world. To develop an effective healthy aging strategy, a tool for assessing aging process is needed. Numerous attempts to quantify the aging process have been made. Read More

View Article and Full-Text PDF
September 2023
Similar Publications
}
© 2023 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap