Evaluation of the early phase of Bell's palsy using 3 T MRI.

Authors:
Hartmut Peter Burmeister
Hartmut Peter Burmeister
Institute of Diagnostic and Interventional Radiology
Germany
Gerd Fabian Volk
Gerd Fabian Volk
Jena University Hospital
Germany
Carsten Michael Klingner
Carsten Michael Klingner
University Hospital-Friedrich Schiller University Jena
Germany
Anke Kraft
Anke Kraft
Hannover Medical School
Hannover | Germany
Matthias Dietzel
Matthias Dietzel
Institute of Diagnostic and Interventional Radiology
Germany
Otto Wilhelm Witte
Otto Wilhelm Witte
University Hospital Jena
Germany
Werner Alois Kaiser
Werner Alois Kaiser
Institute of Diagnostic and Interventional Radiology
Germany

Eur Arch Otorhinolaryngol 2011 Oct 5;268(10):1493-500. Epub 2011 Feb 5.

Institute of Diagnostic and Interventional Radiology, University Hospital-Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany.

This prospective study on Bell's palsy investigated the value of 3 T MRI as a diagnostic tool to evaluate pathophysiological changes (i.e. edema) of facial nerve segments and the possibility to differentiate patients with high risk for incomplete recovery from patients who recover completely within 3 days after symptoms onset. For this institutional review board approved investigation, thirty patients (14 male, 16 female, mean age 44 years) with Bell's palsy underwent pre and postcontrast 3 T MRI of the cerebellopontine angle. T1-weighted imaging was performed (TR 20.0 ms, TE 2.46 ms, isotropic voxel size: 0.6 mm). Region-of-interest measurements were performed on the healthy and paralyzed side. To obtain normalized values, signal intensity increase percentage (SIIP) values were divided by contralateral results of the healthy side. Signal intensity measurements of examined nerve segments were compared using Wilcoxon and Mann-Whitney U tests and correlated to clinical findings categorized by the House-Brackmann score. The lesion side showed significantly higher signal intensities in the premeatal segment before and after contrast agent administration (P < 0.001). SIIP was highest in the premeatal segment compared to the geniculate ganglion (P < 0.001). Correlation analyses revealed no association between signal intensity measurements, clinical findings or early recovery rates after 3 months (P > 0.05). According to our results, early palsy-associated pathophysiological changes in the facial nerve premeatal segment might also be related to accumulation of proteins and not exclusively to edema. However, contrast agent enhancement quantification was not suitable as a diagnostic tool to distinguish different prognostic groups.

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October 2011
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