G protein-coupled receptor kinase 2 in patients with acute myocardial infarction.

Authors:
Gaetano Santulli
Gaetano Santulli
Federico II University of Naples
Italy
Alfonso Campanile
Alfonso Campanile
Ospedale Maggiore Policlinico
Letizia Spinelli
Letizia Spinelli
University Federico II
Italy
Michele Ciccarelli
Michele Ciccarelli
University of Salerno
Fisciano | Italy
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy

Am J Cardiol 2011 Apr 4;107(8):1125-30. Epub 2011 Feb 4.

Division of Internal Medicine, Department of Clinical Medicine and Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy.

Lymphocyte G protein-coupled receptor kinase 2 (GRK2) levels are increased in patients with chronic heart failure, and in this condition, they correlate with cardiac function. The aim of this study was to assess the prognostic role of GRK2 during acute cardiac dysfunction in humans. A study was designed to investigate the role of GRK2 levels in patients with acute coronary syndromes. Lymphocyte GRK2 levels were examined at admission and after 24 and 48 hours in 42 patients with acute coronary syndromes, 32 with ST-segment elevation myocardial infarction and 10 with unstable angina as a control group. Echocardiographic parameters of systolic and diastolic function and left ventricular remodeling were evaluated at admission and after 2 years. GRK2 levels increased during ST-segment elevation myocardial infarction and were associated with worse systolic and diastolic function. This association held at 2-year follow-up, when GRK2 was correlated with the ejection fraction and end-systolic volume, indicating a prognostic value for GRK2 levels during acute ST-segment elevation myocardial infarction. In conclusion, lymphocyte GRK2 levels increase during acute myocardial infarction and are associated with worse cardiac function. Taken together, these data indicate that GRK2 could be predictive of ventricular remodeling after myocardial infarction and could facilitate the tailoring of appropriate therapy for high-risk patients.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjcard.2010.12.006DOI Listing
April 2011
9 Reads
28 Citations
3.280 Impact Factor

Publication Analysis

Top Keywords

grk2 levels
24
myocardial infarction
24
patients acute
12
elevation myocardial
12
st-segment elevation
12
grk2
9
associated worse
8
role grk2
8
levels increased
8
infarction associated
8
ventricular remodeling
8
coronary syndromes
8
acute coronary
8
systolic diastolic
8
diastolic function
8
lymphocyte grk2
8
cardiac function
8
acute myocardial
8
protein-coupled receptor
8
receptor kinase
8

Similar Publications