TAR-DNA binding protein-43 and alterations in the hippocampus.

J Neural Transm (Vienna) 2011 May 6;118(5):683-9. Epub 2011 Jan 6.

Department of Pathology, Kuopio University Hospital, Kuopio, Finland.

Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and α-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00702-010-0574-5DOI Listing
May 2011
21 Reads

Publication Analysis

Top Keywords

hippocampal pathology
12
pathology
9
tdp43-immunoreactive pathology
8
granular cell
8
subjects hippocampal
8
cell layer
8
binding protein-43
8
severe alzheimer's
4
subjects severe
4
alzheimer's disease-related
4
hippocampus routine
4
disease-related pathology
4
displayed tdp43-immunoreactive
4
42% displayed
4
included 42%
4
pathology included
4
included subjects
4
origin included
4
hippocampus percentage
4
layer hippocampus
4

References

(Supplied by CrossRef)

I Alafuzoff et al.
Stroke 1999

I Alafuzoff et al.
Brain Pathol 2008

I Alafuzoff et al.
Acta Neuropathol 2009

I Alafuzoff et al.
Acta Neuropathol 2009

C Amador-Ortiz et al.
Ann Neurol 2007

T Arai et al.
Biochem Biophys Res Commun 2006

T Arai et al.
Acta Neuropathol 2009

H Braak et al.
Acta Neuropathol 2006

AS Chen-Plotkin et al.
Nat Rev Neurol 2010

SH Freeman et al.
J Neuropathol Exp Neurol 2008

H Fujishiro et al.
Acta Neuropathol 2009

Similar Publications