Risperidone-induced weight gain in referred children with autism spectrum disorders is associated with a common polymorphism in the 5-hydroxytryptamine 2C receptor gene.

J Child Adolesc Psychopharmacol 2010 Dec;20(6):473-7

Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Weight gain is an important adverse effect of risperidone, but predictors of significant weight gain have yet to be identified in pediatric patients. Here, we investigated differences between age- and gender-normed body mass index-standardized z scores at baseline and after 8 weeks of open-label, flexible-dose risperidone treatment (mean dose: 1.70  mg/day) in 32 youths with pervasive developmental disorder (mean age = 8.74, range = 5-16 years) in relation to -759C/T 5-hydroxytryptamine 2C receptor (HTR2C) promoter and rs1414334 HTR2C intragenic C/G alleles, along with gender, age, and risperidone dose, using repeated measures analyses of variance. Carriers of the HTR2C promoter T allele gained an average of 0.043 ± 0.017 body mass index-standardized z scores (1.84 ± 1.51  kg) versus 0.64 ± 0.35 z (3.23 ± 1.47  kg) for non-T-allele carriers (p < 0.001). Presence of the rs1414334 C allele played no significant role. Further, weight gain appeared to be associated with younger age and higher doses of risperidone. The current preliminary findings suggest that the variant T allele of the -759C/T HTR2C promoter polymorphism is protective against risperidone-induced weight gain. Younger children and those treated with higher doses of risperidone may be at higher risk for weight gain.

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/cap.2009.0071
Publisher Site
http://dx.doi.org/10.1089/cap.2009.0071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003450PMC
December 2010
21 Reads

Publication Analysis

Top Keywords

weight gain
12
mass index-standardized
8
index-standardized scores
8
htr2c promoter
8
5-hydroxytryptamine receptor
8
body mass
8
allele gained
4
risperidone dose
4
carriers p 
4
scores baseline
4
years relation
4
weeks open-label
4
promoter allele
4
baseline weeks
4
relation -759c/t
4
-759c/t 5-hydroxytryptamine
4
gained average
4
investigated differences
4
developmental disorder
4
differences age-
4

Similar Publications