Proteomics 2011 Jan 6;11(1):166-71. Epub 2010 Dec 6.
Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW, Australia.
Microbiol Spectr 2021 Jul 28:e0049621. Epub 2021 Jul 28.
Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Prostaglandin E2 (PGE2) is an essential immunomodulatory lipid released by cells in response to infection with many bacteria, yet its function in macrophage-mediated bacterial clearance is poorly understood. overall inhibits the inflammatory circuit, but its effect on PGE2 production is unknown. We hypothesized that one of the effector proteins is responsible for the inhibition of PGE2 biosynthesis. Read More
Food Technol Biotechnol 2021 Jun;59(2):201-208
Medicinal Mushroom Research Group, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Research Background: a highly valued medicinal fungus, is close to extinction due to overexploitation. Successful cultivation of fruiting body (OCS02®) shows that the cultivar has a promising nutritional value and numerous bioactive compounds. Antioxidant and antiproliferative properties and biologically active proteins of the OCS02® are investigated for possible development into nutraceuticals. Read More
Proteomics 2021 Jul 27:e2000319. Epub 2021 Jul 27.
Department of Environmental Science and Policy, University of Milan, Milan, Italy.
In this study we investigated the performance of a computational pipeline for protein identification and label free quantification of LC-MS/MS data sets from experimental animal tissue samples, as well as the impact of its specific peptide search combinatorial approach. The full pipeline workflow was composed of peptide search engine adapters based on different identification algorithms, in the frame of the open-source OpenMS software running within the KNIME analytics platform. Two different in silico tryptic digestion, database-search assisted approaches (X!Tandem and MS-GF+), de novo peptide sequencing based on Novor and consensus library search (SpectraST), were tested for the processing of LC-MS/MS raw datafiles obtained from proteomic LC-MS experiments done on proteolytic extracts from mouse ex-vivo liver samples. Read More
Food Chem Toxicol 2021 Jul 21:112435. Epub 2021 Jul 21.
Departamento de Anatomía y Anatomía Patológica Comparadas y Toxicología. Facultad de Veterinaria. Universidad de Córdoba, Campus de Rabanales, 14014, Córdoba, Spain.
Human exposure to bisphenol-A (BPA) is largely unavoidable because BPA is an environmental contaminant found in soil, water, food and indoor dust. The safety of authorized BPA amounts in consumer products is under question because new studies have reported adverse effects of BPA at doses far below that previously established by the NOAEL (50 μg/kg per day). To protect public health, the consequences of low-dose BPA exposure in different organs and organismal functions must be further studied to generate relevant data. Read More
J Proteomics 2021 Jul 20:104332. Epub 2021 Jul 20.
Department of Veterinary Economics and Epidemiology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.
Liver fluke, Fascioloides magna, is an important non-native parasite introduced to Europe, posing a threat to survival of local wildlife populations. The aim of this study is to assess the serum and liver protein profile of control and F. magna infected wild boars, by means of shotgun tandem mass tag - based quantitative high resolution proteomic approach. Read More