Association of HLA-A*02:06 and HLA-DRB1*04:05 with clinical subtypes of juvenile idiopathic arthritis.

J Hum Genet 2011 Mar 23;56(3):196-9. Epub 2010 Dec 23.

Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Juvenile idiopathic arthritis (JIA) is one of the most common forms of pediatric chronic arthritis. JIA is a clinically heterogeneous disease. Therefore, the genetic background of JIA may also be heterogeneous. The aim of this study was to investigate associations between human leukocyte antigen (HLA) and susceptibility to JIA and/or uveitis, which is one of the most devastating complications of JIA. A total of 106 Japanese articular JIA patients (67 with polyarthritis and 39 with oligoarthritis) and 678 healthy controls were genotyped for HLA-A, -B and -DRB1 by PCR-sequence-specific oligonucleotide probe methodology. HLA-A(*)02:06 was the risk factor for JIA accompanied by uveitis after adjustment for clinical factors (corrected P-value < 0.001, odds ratio (OR) 11.7, 95% confidence interval (CI) 3.2-43.0). On the other hand, HLA-DRB1(*)04:05 was associated with polyarticular JIA (corrected P-value < 0.001, OR 2.9, 95% CI 1.7-4.8). We found an association of HLA-A(*)02:06 with susceptibility to JIA accompanied by uveitis, which might be considered a separate clinical JIA entity. We also found an association between HLA-DRB1(*)04:05 and polyarticular JIA. Thus, clinical subtypes of JIA can be classified by the presence of the specific HLA alleles, HLA-A(*)02:06 and DRB1(*)04:05.

Download full-text PDF

Source
http://dx.doi.org/10.1038/jhg.2010.159DOI Listing
March 2011
6 Reads

Publication Analysis

Top Keywords

jia
12
corrected p-value
8
jia accompanied
8
idiopathic arthritis
8
p-value 0001
8
arthritis jia
8
accompanied uveitis
8
juvenile idiopathic
8
polyarticular jia
8
susceptibility jia
8
clinical subtypes
8
association hla-a*0206
8
oligoarthritis 678
4
hla-a*0206 susceptibility
4
patients polyarthritis
4
17-48 association
4
polyarthritis oligoarthritis
4
genotyped hla-a
4
95% 17-48
4
controls genotyped
4

References

(Supplied by CrossRef)

M Mori et al.
Mod. Rheumatol. 2009

RE Petty et al.
J. Rheumatol. 2004

MR Kesen et al.
Int. Ophthalmol. Clin. 2008

WP Madigan et al.
J. Pediatr. Ophthalmol. Strabismus. 2008

A Grassi et al.
J. Rheumatol. 2007

RK Saurenmann et al.
Arthritis Rheum. 2007

KJ Zamecki et al.
Am. J. Ophthalmol. 2010

E Zeggini et al.
Rheumatology (Oxford) 2006

Y Itoh et al.
Immunogenetics 2005

Y Date et al.
Tissue Antigens 1996

A Kimura et al.
Tissue Antigens 1992

Similar Publications