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Revalidation of description of constipation in terms of recall bias and visual scale analog questionnaire.
Methods: Seven hundred and sixty healthy hospital personnel were questioned by means of a standard questionnaire. Read More
Methods: In 190 patients with chronic constipation (age, 53 (range, 18-88) years; 85 percent of whom were women), symptom evaluation, transit time measurement (radiopaque markers), and functional rectoanal evaluation (proctoscopy, anorectal manometry, defecography) were performed. Patients were classified on the basis of objective data from all tests in four different groups ("disordered defecation," "slow gastrointestinal transit," "disordered defecation combined with slow-transit stool," and "no pathologic finding"). Read More
- Anthony J Lembo,
- Caroline B Kurtz,
- James E Macdougall,
- B J Lavins,
- Mark G Currie,
- Donald A Fitch,
- Brenda I Jeglinski,
- Jeffrey M Johnston
Methods: We performed a multicenter, double-blind, placebo-controlled, parallel-group study of 310 patients with chronic constipation. Read More
Effect of MKC-733, a 5-HT receptor partial agonist, on bowel motility and symptoms in subjects with constipation: an exploratory study.
Objective: The aim of this study was to explore the effects of MKC-733 on bowel motility and symptoms in a small group of subjects with constipation. Tolerability was also examined. Read More