The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse.

PLoS One 2010 Nov 18;5(11):e14047. Epub 2010 Nov 18.

Department of Biochemistry and Magdalen College, University of Oxford, Oxford, United Kingdom.

Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria. They are the second largest subfamily of seven-transmembrane spanning proteins in vertebrates, but the function of most of these receptors is still not understood. The orphan Adhesion-GPCR GPR126 has recently been shown to play an essential role in the myelination of peripheral nerves in zebrafish. In parallel, whole-genome association studies have implicated variation at the GPR126 locus as a determinant of body height in the human population. The physiological function of GPR126 in mammals is still unknown. We describe a targeted mutation of GPR126 in the mouse, and show that GPR126 is required for embryonic viability and cardiovascular development.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014047PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987804PMC
November 2010
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