Dietary glycemic load and risk of colorectal cancer in Chinese women.

Am J Clin Nutr 2011 Jan 20;93(1):101-7. Epub 2010 Oct 20.

Shanghai Cancer Institute, Shanghai, China.

Background: Mixed results have been reported in recent epidemiologic studies in Western populations that have investigated the hypothesis that high glycemic load may increase the risk of colorectal cancer. This association has not been prospectively evaluated in other populations.

Objective: We examined the association of overall glycemic index and glycemic load with colorectal cancer risk in a prospective cohort of Chinese women.

Design: A total of 73,061 women aged 40-70 y and free of cancer at enrollment were included in this analysis. Usual dietary intake was assessed at baseline (1997-2000) and reassessed during the first follow-up (2000-2002) through in-person interviews by using a validated food-frequency questionnaire.

Results: During an average follow-up of 9.1 y, 475 incident colorectal cancer cases were identified. Glycemic load was not associated with colorectal cancer risk (P for trend = 0.84). The multivariable hazard ratio for the highest compared with the lowest quintile of glycemic load was 0.94 (95% CI: 0.71, 1.24). Similar results were also observed for associations with dietary glycemic index and total carbohydrate intake, and results did not vary by excluding individuals with a history of diabetes from the analysis.

Conclusion: This prospective study, conducted in a population with a high intake of carbohydrates, provides no evidence that a high-glycemic index diet or high glycemic load is associated with an increased risk of colorectal cancer.

Download full-text PDF

Source
http://dx.doi.org/10.3945/ajcn.110.003053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001600PMC
January 2011
12 Reads

Publication Analysis

Top Keywords

colorectal cancer
24
glycemic load
24
risk colorectal
12
dietary glycemic
8
cancer risk
8
high glycemic
8
load associated
8
glycemic
7
cancer
7
colorectal
6
load
6
risk
5
identified glycemic
4
cases identified
4
incident colorectal
4
cancer cases
4
475 incident
4
084 multivariable
4
hazard ratio
4
ratio highest
4

Altmetric Statistics

References

(Supplied by CrossRef)
Global cancer statistics, 2002
Parkin et al.
CA Cancer J Clin 2005
Cancer statistics, 2010
Jemal et al.
CA Cancer J Clin 2010
Cancer incidence, mortality and survival rates in urban Shanghai (1973-2000)
Gao et al.
2007
Colon cancer: a review of the epidemiology
Potter et al.
Epidemiol Rev 1993
Obesity, gender, and colon cancer
Giovannucci et al.
Gut 2002
Modifiable risk factors for colon cancer
Giovannucci et al.
Gastroenterol Clin North Am 2002

Similar Publications