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Stem Cells Int 2021 30;2021:5583994. Epub 2021 Mar 30.

Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013 Jiangsu, China.

Research on mesenchymal stem cells (MSCs) starts from the earliest assumption that cells derived from the bone marrow have the ability to repair tissues. Several scientists have since documented the crucial role of bone marrow-derived MSCs (BM-MSCs) in processes such as embryonic bone and cartilage formation, adult fracture and tissue repair, and immunomodulatory activities in therapeutic applications. In addition to BM-MSCs, several sources of MSCs have been reported to possess tissue repair and immunoregulatory abilities, making them potential treatment options for many diseases. Read More

Otol Neurotol 2021 Apr 14. Epub 2021 Apr 14.

Kolling Deafness Research Centre, Royal North Shore Hospital, University of Sydney Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Objective: Pneumatoceles of the temporal bone are rare entities. A symptomatic external auditory canal pneumatocele repaired endoscopically is demonstrated.

Methods: A 79-year-old man presented with fluctuating hearing loss and difficulty wearing in-ear hearing aids. Read More

Cartilage 2021 Apr 15:19476035211007923. Epub 2021 Apr 15.

Department of Immunology, Oslo University Hospital, Oslo, Norway.

Objective: Despite new strategies in tissue engineering, cartilage repair remains a major challenge. Our aim is to treat patients with focal lesions of articular cartilage with autologous hyaline cartilage implants using a scaffold-free approach. In this article, we describe experiments to optimize production of scaffold-free cartilage discs. Read More

Knee 2021 Apr 12;30:51-62. Epub 2021 Apr 12.

Department of Orthopaedics, Royal Darwin Hospital, 105 Rocklands Drive, Tiwi, NT 0810, Australia. Electronic address:

Background: Articular chondroprogenitors are a promising contender for cartilage repair due to their inherent nature which stands primed for chondrogenesis and minimal hypertrophic preponderance. Platelet rich plasma (PRP) has been extensively used for treating cartilage defects and osteoarthritis (OA), due to its chondro-inductive properties and abundant pool of growth factors. The aim of this study was to assess the efficacy of chondroprogenitors injected with PRP versus PRP alone in the healing of experimentally created early OA and osteochondral defects (OCD) in a rabbit model. Read More

J Tissue Eng 2021 Jan-Dec;12:20417314211004816. Epub 2021 Mar 30.

Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.

Mesenchymal stem cells (MSCs) are a potential source of cell-based disease-modifying therapy in Parkinsonian disorders. A promising approach to develop in vitro culture methods that mimic natural MSC niche is cell priming. Uric acid (UA), a powerful antioxidant, scavenges reactive oxygen species, which has a vital role in maintaining self-renewal and differentiation potential of MSCs. Read More