Stringent programming of DNA methylation in humans.

Twin Res Hum Genet 2010 Oct;13(5):405-11

School of Chemistry and Molecular Biosciences, The University of Queensland, Australia.

We describe a PCR-based method called Amplified Methylation Polymorphism (AMP) for scanning genomes for DNA methylation changes. AMP detects tissue-specific DNA methylation signatures often representing junctions between methylated and unmethylated DNA close to intronexon junctions and/or associated with CpG islands. Identical AMP profiles are detected for healthy, young, monozygotic twins.

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http://dx.doi.org/10.1375/twin.13.5.405DOI Listing
October 2010
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