The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance.

Ann Rheum Dis 2011 May 24;70(5):873-5. Epub 2010 Sep 24.

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http://dx.doi.org/10.1136/ard.2010.134155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699799PMC
May 2011
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