Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

NF-κB and innate immunity.

Authors:
Anurupa Dev Shankar Iyer Bahram Razani Genhong Cheng

Curr Top Microbiol Immunol 2011 ;349:115-43

Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, 615 Charles Young Dr S., 210A BSRB, Los Angeles, CA 90095, USA.

Members of the NF-κB transcription factor family play a critical role in the development of innate immunity. Upon recognition of pathogen infections or tissue damage, the NF-κB pathway is strongly activated by cellular pattern recognition receptors, including Toll-like receptors and multiple cytosolic receptors such as RIG-I-like helicases and NOD family proteins. NF-κB is required not only for the expression, but also for subsequent signal transduction of numerous downstream cytokines. NF-κB-responsive genes affect a diverse array of cellular processes including apoptosis and cell survival, and often directly control the course of a pathogen infection. In this review, we will examine signaling pathways leading to NF-κB activation during the innate immune response and mechanisms of pathogen-modulation of these pathways; the specifics of NF-κB-dependent gene programs, and the physiological consequences for the immune system caused by the absence of individual NF-κB subunits.

Download full-text PDF

Source
http://dx.doi.org/10.1007/82_2010_102DOI Listing
August 2011

Publication Analysis

Top Keywords

innate immunity
8
nf-κb
6
nf-κb required
4
specifics nf-κb-dependent
4
control course
4
proteins nf-κb
4
family proteins
4
pathways specifics
4
pathogen-modulation pathways
4
subsequent signal
4
expression subsequent
4
course pathogen
4
required expression
4
nod family
4
cytosolic receptors
4
multiple cytosolic
4
signaling pathways
4
receptors multiple
4
gene programs
4
receptors rig-i-like
4

Keyword Occurance

Similar Publications

NLRP3 as a sensor of metabolism gone awry.

Authors:
Emilia Neuwirt Oliver Gorka Benedikt S Saller Christina J Groß Tobias Madl Olaf Groß

Curr Opin Biotechnol 2021 Apr 12;68:300-309. Epub 2021 Apr 12.

Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany. Electronic address:

The NLRP3 inflammasome is an important player in innate immunity and pathogenic inflammation. Numerous studies have implicated it in sensing endogenous danger signals, yet the precise mechanisms remain unknown. Here, we review the current knowledge on the organismal and cellular metabolic triggers engaging NLRP3, and the mechanisms involved in integrating the diverse signals. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

An invertebrate gene encoding a Mab21-containing protein involves in antiviral response through regulating the STING pathway.

Authors:
Shihao Li Feifei Yang Fuxuan Wang Xinjia Lv Fuhua Li

Dev Comp Immunol 2021 Apr 13:104101. Epub 2021 Apr 13.

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, China. Electronic address:

The cGAS-STING pathway plays essential roles in detecting cytosolic dsDNA and initiating antiviral and antibacterial responses in vertebrates. However, knowledge about its function in antiviral response of invertebrates is very limited. In the present study, a gene encoding a Mab21-containing protein, a cGAS homologue, was identified from a decapod crustacean Litopenaeus vannamei and designated as LvMab21cp. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Nuts and bolts of the salt-inducible kinases (SIKs).

Authors:
Nicola J Darling Philip Cohen

Biochem J 2021 Apr;478(7):1377-1397

MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Dundee, U.K.

The salt-inducible kinases, SIK1, SIK2 and SIK3, most closely resemble the AMP-activated protein kinase (AMPK) and other AMPK-related kinases, and like these family members they require phosphorylation by LKB1 to be catalytically active. However, unlike other AMPK-related kinases they are phosphorylated by cyclic AMP-dependent protein kinase (PKA), which promotes their binding to 14-3-3 proteins and inactivation. The most well-established substrates of the SIKs are the CREB-regulated transcriptional co-activators (CRTCs), and the Class 2a histone deacetylases (HDAC4/5/7/9). Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages.

Authors:
Kathy Triantafilou Christopher J K Ward Magdalena Czubala Robert G Ferris Emma Koppe Curt Haffner Vincent Piguet Vipulkumar K Patel Heather Amrine-Madsen Louise Modis Seth L Masters Martha Triantafilou

PLoS Pathog 2021 Apr 16;17(4):e1009417. Epub 2021 Apr 16.

Immunology Catalyst, Immunology Network, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.

Macrophages are important drivers of pathogenesis and progression to AIDS in HIV infection. The virus in the later phases of the infection is often predominantly macrophage-tropic and this tropism contributes to a chronic inflammatory and immune activation state that is observed in HIV patients. Pattern recognition receptors of the innate immune system are the key molecules that recognise HIV and mount the inflammatory responses in macrophages. Read More

View Article and Full-Text PDF
April 2021
Similar Publications

Individuals with isolated congenital GH deficiency due to a GHRH receptor gene mutation appear to cope better with SARS-CoV-2 infection than controls.

Authors:
Manuela A Melo Lysandro P Borges Roberto Salvatori Daniela R V Souza Hertz T Santos-Júnior José M de R Neto Viviane C Campos Aryanne A Santos Carla R P Oliveira Grazielly B da Invenção Vanderlan O Batista Igor L S Matos Cynthia S Barros-Oliveira Kezia A Dos Santos Elenilde G Santos Nicolas A A Souza Enaldo V Melo Pamela C Borges Saulo E F S Santos Brenda M de Oliveira Alécia A Oliveira-Santos Amélia R de Jesus Manuel H Aguiar-Oliveira

Endocrine 2021 Apr 16. Epub 2021 Apr 16.

Division of Endocrinology, Health Sciences Graduate Program, Aracaju, Brazil.

Purpose: Several interactions exist between the GH/IGF axis and the immune system, including effects on innate immunity and humoral and cellular response. Acquired GH deficiency (GHD) has been recently proposed as a risk factor for severity of COVID-19 infections. However, acquired GHD is often associated to other factors, including pituitary tumors, surgery, radiotherapy, and additional pituitary hormones deficits and their replacements, which, together, may hinder an accurate analysis of the relationship between GHD and COVID-19. Read More

View Article and Full-Text PDF
April 2021
Similar Publications
© 2021 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap