Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells.

J Neurooncol 2011 Jun 14;103(2):187-95. Epub 2010 Sep 14.

Brain Tumour Center, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Interferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation of glioma cells in a time-dependent manner. The growth inhibitory effect was mediated by cell cycle arrest. Furthermore, IFITM1 knockdown significantly inhibited migration and invasion of glioma cells, which could be attributed to decreased expression and enzymatic activity of matrix metalloproteinase 9. Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas.

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http://dx.doi.org/10.1007/s11060-010-0377-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097340PMC
June 2011
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References

(Supplied by CrossRef)

H Ohgaki et al.
Acta Neuropathol 2005

EA Maher et al.
Gene Dev 2001

R Stupp et al.
New Engl J Med 2005

AR Lewin et al.
Eur J Biochem 1991

S Sato et al.
J Immunol 1997

SS Tanaka et al.
Dev Cell 2005

C Wylie et al.
Dev Cell 2005

Y Yang et al.
Cancer Lett 2005

H Hatano et al.
Clin Cancer Res 2008

NT Seyfried et al.
Cancer Lett 2008

P Andreu et al.
Cancer Res 2006

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