Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.

Authors:
Li-Dong Wang Fu-You Zhou Xue-Min Li Liang-Dan Sun Xin Song Yan Jin Jiang-Man Li Guo-Qiang Kong Hong Qi Juan Cui Lian-Qun Zhang Jie-Zhi Yang Ji-Lin Li Xing-Chuan Li Jing-Li Ren Zhi-Cai Liu Wen-Jun Gao Ling Yuan Wu Wei Yan-Rui Zhang Wei-Peng Wang Ilyar Sheyhidin Feng Li Bao-Ping Chen Shu-Wei Ren Bin Liu Dan Li Jian-Wei Ku Zong-Min Fan Sheng-Li Zhou Zhi-Gang Guo Xue-Ke Zhao Na Liu Yong-Hong Ai Fang-Fang Shen Wen-Yan Cui Shuang Song Tao Guo Jing Huang Chao Yuan Jia Huang Yue Wu Wen-Bin Yue Chang-Wei Feng Hong-Lei Li Yan Wang Jin-Ya Tian Yue Lu Yi Yuan Wen-Liang Zhu Min Liu Wen-Jing Fu Xia Yang Han-Jing Wang Suo-Li Han Jie Chen Min Han Hai-Yan Wang Peng Zhang Xiu-Min Li Jin-Cheng Dong Guo-Lan Xing Ran Wang Ming Guo Zhi-Wei Chang Hai-Lin Liu Li Guo Zhi-Qing Yuan Hai Liu Qin Lu Liu-Qin Yang Fu-Guo Zhu Xiu-Feng Yang Xiao-Shan Feng Zhou Wang Yin Li She-Gan Gao Qirenwang Qige Long-Tang Bai Wen-Jun Yang Guang-Yan Lei Zhong-Ying Shen Long-Qi Chen En-Min Li Li-Yan Xu Zhi-Yong Wu Wei-Ke Cao Jian-Po Wang Zhi-Qin Bao Ji-Li Chen Guang-Cheng Ding Xiang Zhuang Ying-Fa Zhou Hou-Feng Zheng Zheng Zhang Xian-Bo Zuo Zi-Ming Dong Dong-Mei Fan Xin He Jin Wang Qi Zhou Qin-Xian Zhang Xin-Ying Jiao Shi-Yong Lian Ai-Fang Ji Xiao-Mei Lu Jin-Sheng Wang Fu-Bao Chang Chang-Dong Lu Zhi-Guo Chen Jian-Jun Miao Zeng-Lin Fan Ruo-Bai Lin Tai-Jiang Liu Jin-Chang Wei Qing-Peng Kong Yu Lan Yu-Jing Fan Fu-Sheng Gao Tian-Yun Wang Dong Xie Shu-Qing Chen Wan-Cai Yang Jun-Yan Hong Liang Wang Song-Liang Qiu Zhi-Ming Cai Xue-Jun Zhang

Nat Genet 2010 Sep 22;42(9):759-63. Epub 2010 Aug 22.

Cancer Research Center, Xinxiang Medical University, Xinxiang, Henan, China.

We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.648DOI Listing
September 2010
112 Reads

Publication Analysis

Top Keywords

control subjects
16
subjects chinese
12
escc
11
han descent
8
susceptibility loci
8
combined escc
8
phan combined
8
plce1 c20orf54
8
cases escc
8
escc gca
8
puygur-kazakh escc
8
phan gca
8
chinese han
8
11013 control
8
esophageal squamous
8
study esophageal
8
association study
8
squamous cell
8
cell carcinoma
8
genome-wide association
8

Altmetric Statistics

References

(Supplied by CrossRef)

DM Parkin et al.
CA Cancer J. Clin. 2005

L Ke et al.
Int. J. Cancer 2002

M Hongo et al.
J. Gastroenterol. Hepatol. 2009

WY Cheung et al.
Gastroenterol. Clin. North Am. 2009

F Siassi et al.
Cancer Detect. Prev. 2005

CX Yang et al.
Asian Pac. J. Cancer Prev. 2005

G Sun et al.
Food Addit. Contam. 2007

M Morita et al.
Int. J. Clin. Oncol. 2010

H Messmann et al.
Best Pract. Res. Clin. Gastroenterol. 2001

LM Brown et al.
Am. J. Epidemiol. 2001

Similar Publications