J Antimicrob Chemother 2010 Oct 17;65(10):2264-5. Epub 2010 Aug 17.
Antimicrob Agents Chemother 2021 Jun 7:AAC0050821. Epub 2021 Jun 7.
Department of Medicine, Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
We utilized the rabbit model of aortic valve infective endocarditis to examine the combined efficacy of the lysin, LSVT-1701, plus daptomycin. The combination of LSVT-1701 plus daptomycin was highly effective at reducing target tissue MRSA counts. When given for four daily doses, both lysin dose-regimens in combination with daptomycin sterilized all target tissues. Read More
Pathogens 2021 May 2;10(5). Epub 2021 May 2.
Department of Microbiology, "Grigore T. Popa" University of Medicine and Pharmacy, 6 University Street, 700115 Iasi, Romania.
Objective: This study aimed to identify possible differences between blood culture-negative and blood culture-positive groups of infective endocarditis (IE), and explore the associations between biological parameters and in-hospital mortality.Methods: This was a retrospective study of patients hospitalized for IE between 2007 and 2017. Epidemiological, clinical and paraclinical characteristics, by blood culture-negative and positive groups, were collected. Read More
Subst Abus 2021 May 26:1-6. Epub 2021 May 26.
Section of General Internal Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Introduction: Rates of injection-drug use associated infective endocarditis (IDU-IE) are rising, and most patients with IDU-IE do not receive addiction care during hospitalization. We sought to characterize cardiac surgeons' practices and attitudes toward patients with IDU-IE due to their integral role treating them.Methods: This is a survey of 201 cardiac surgeons in the U. Read More
Infect Dis (Lond) 2021 May 26:1-9. Epub 2021 May 26.
Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, University Hospital Virgen Macarena, Department of Medicine, University of Seville, Institute of Biomedicine of Seville (IBiS), Sevilla, Spain.
Background: To assess the impact of blood cultures negative infective endocarditis (BCNIE) on in-hospital mortality.Methods: Prospective multicentre study with retrospective analysis of a Spanish cohort including adult patients with definite IE. Cardiac implantable devices infection were excluded. Read More
Am J Med Sci 2021 May 22. Epub 2021 May 22.
Division of Cardiovascular Medicine, West Virginia University Heart & Vascular Institute, Morgantown, WV, USA.
Background: Prosthetic valve endocarditis (PVE) carries high mortality and morbidity as compared to native valve endocarditis (NVE). Contemporary data on PVE are lacking, we aimed to study contemporary trends, outcomes, and burden of PVE using nationally representative data.Methods: We used the National Inpatient Sample from 2000 to 2017 to identify patients admitted with PVE using ICD-9-CM and ICD-10 codes. Read More