In vitro comparison of foot-and-mouth disease virus subtype variants causing disease in vaccinated cattle.

J Hyg (Lond) 1978 Jun;80(3):451-9

Foot-and-mouth disease virus isolates of types O, A and SAT 2, from diseased animals in herds routinely vaccinated twice a year were compared antigenically with the vaccine strains in the complement-fixation, neutralization and radial immunodiffusion tests. It was found that strains which had readily infected vaccinated cattle had R values against the vaccine strain in the complementfixation and radial immunodiffusion tests of 30 or less, while strains causing primary outbreaks with little spread had R values of 30-40. Threefold differences in humoral neutralizing antibody concentration between the field variant and the vaccine strain in sera from vaccinated animals were likely to be significant in terms of protection.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129798PMC
http://dx.doi.org/10.1017/s002217240002492xDOI Listing
June 1978
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References

(Supplied by CrossRef)
Production of Foot-and-Mouth Disease vaccines against various virus types and subtypes
Pay et al.
Bulletin de l'Office international des épizooties 1974
Die Pluralität des Maul-und Klauenseuchevirus
Traub et al.
Berliner und Münchener Tierärztliche Wochenschrift 1946
Chemical and physical properties of virtually pure Foot-and-Mouth Disease virus
Bachrach et al.
American Journal of Veterinary Research 1964

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