A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4818

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4818
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: author

Filename: helpers/my_audit_helper.php

Line Number: 4830

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4830
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4832

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4832
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4833

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4833
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4818

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4818
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: author

Filename: helpers/my_audit_helper.php

Line Number: 4830

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4830
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4832

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4832
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4833

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4833
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4818

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4818
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: author

Filename: helpers/my_audit_helper.php

Line Number: 4830

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4830
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4832

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4832
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4833

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4833
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4818

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4818
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: author

Filename: helpers/my_audit_helper.php

Line Number: 4830

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4830
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4832

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4832
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4833

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4833
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4818

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4818
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: author

Filename: helpers/my_audit_helper.php

Line Number: 4830

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4830
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4832

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4832
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4833

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4833
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4818

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4818
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: author

Filename: helpers/my_audit_helper.php

Line Number: 4830

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4830
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4832

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4832
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4833

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4833
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4818

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4818
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: author

Filename: helpers/my_audit_helper.php

Line Number: 4830

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4830
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4832

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4832
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4833

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4833
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4818

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4818
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: author

Filename: helpers/my_audit_helper.php

Line Number: 4830

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4830
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4832

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4832
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4833

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4833
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4818

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4818
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: author

Filename: helpers/my_audit_helper.php

Line Number: 4830

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4830
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4831

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4831
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4832

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4832
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: year

Filename: helpers/my_audit_helper.php

Line Number: 4833

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4833
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: journal-title

Filename: helpers/my_audit_helper.php

Line Number: 4818

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 4818
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 48
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Notice

Message: Undefined index: author

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Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression. | PubFacts

Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression.

Authors:
Daniela Sorriento
Daniela Sorriento
Department of Clinical Medicine
Italy
Gaetano Santulli
Gaetano Santulli
Federico II University of Naples
Italy
Anna Fusco
Anna Fusco
Federico II University
Antonio Anastasio
Antonio Anastasio
Department of Clinical Medicine
Italy
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy

Hypertension 2010 Oct 26;56(4):696-704. Epub 2010 Jul 26.

Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy.

Several studies underline the role of the transcription factor NF-κB in the development of left cardiac hypertrophy (LVH). We have demonstrated recently that the RGS homology domain within the amino terminus of GRK5 (GRK5-NT) is able to inhibit NF-κB transcription activity and its associated phenotypes. The aim of this study was to evaluate the ability of GRK5-NT to regulate LVH through the inhibition of NF-κB both in vitro and in vivo. In cardiomyoblasts, GRK5-NT inhibits phenylephrine-induced transcription of both NF-κB and atrial natriuretic factor promoters, assessed by luciferase assay, thus confirming a role for this protein in the regulation of cardiomyocyte hypertrophy. In vivo, we explored 2 rat models of LVH, the spontaneously hypertensive rat and the normotensive Wistar Kyoto rat exposed to chronic administration of phenylephrine. Intracardiac injection of an adenovirus encoding for GRK5-NT reduces cardiac mass in spontaneously hypertensive rats and prevents the development of phenylephrine-induced LVH in Wistar Kyoto rats. This associates with inhibition of NF-κB signaling (assessed by NF-κB levels), transcriptional activity and phenotypes (fibrosis and apoptosis). Such phenomenon is independent from hemodynamic changes, because adenovirus encoding for GRK5-NT did not reduce blood pressure levels in spontaneously hypertensive rats or in Wistar Kyoto rats. In conclusion, our study supports the regulation of LVH based on the GRK5-NT inhibition of the NF-κB transduction signaling.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.155960DOI Listing
October 2010
21 Reads
48 Citations
6.480 Impact Factor

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