Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.

Nat Genet 2010 Aug 18;42(8):661-4. Epub 2010 Jul 18.

School of Public Health, University of California, Berkeley, Berkeley, California, USA.

To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).

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http://dx.doi.org/10.1038/ng.626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913472PMC
August 2010
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References

(Supplied by CrossRef)

CF Skibola et al.
Haematologica 2007

CF Skibola et al.
Nat. Genet. 2009

CF Skibola et al.
PLoS One 2008

KE Smedby et al.
J. Natl. Cancer Inst. 2005

JR Cerhan et al.
Blood 2007

MC Di Bernardo et al.
Nat. Genet. 2008

PI de Bakker et al.
Nat. Genet. 2006

W Klitz et al.
Tissue Antigens 2003

Y Al-Tonbary et al.
Hematology 2004

O Nathalang et al.
Eur. J. Immunogenet. 1999

HB Choi et al.
Int. J. Hematol. 2008

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