Toxicol Sci 2010 Nov 14;118(1):71-85. Epub 2010 Jul 14.
Preclinical Safety Profiling, CPC, Novartis Institutes of Biomedical Research, Inc., Cambridge, Massachusetts 02139, USA.
Eur J Med Chem 2021 Feb 9;216:113265. Epub 2021 Feb 9.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. Electronic address:
Tropomyosin receptor kinase (TRK) represents an attractive oncology target for cancer therapy related to its critical role in cancer formation and progression. NTRK fusions are found to occur in 3.3% of lung cancers, 2. Read More
Food Chem 2021 Feb 20;352:129331. Epub 2021 Feb 20.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education), Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China. Electronic address:
A novel density-tunable liquid-phase microextraction (DT-LPME) system was developed with high-density deep eutectic solvents (DESs) as extractant and low-density organic solvents as emulsifier and density regulator. DES-rich phase was induced to form in the bottom or in the top by adjusting the emulsifier amount. This system was used to directly extract polycyclic aromatic hydrocarbons (PAHs) from liquid and solid foods, and the obtained DES-rich phase was easy to be collected for quantification. Read More
J Thorac Oncol 2021 Feb 27. Epub 2021 Feb 27.
Gustave Roussy, 114, rue Édouard-Vaillant 94805 Villejuif Cedex - France; Paris-Saclay University, Espace Technologique Bat. Discovery - RD 128, 2e ét, 91190 Saint-Aubin, France.
Introduction: This open-label, phase I/II study assessed safety and efficacy of rovalpituzumab tesirine (Rova-T™), an antibody-drug conjugate targeting delta-like protein 3 plus immune checkpoint inhibitors nivolumab ± ipilimumab in previously treated extensive-stage small cell lung cancer (ES SCLC).Methods: Patients with histologically/cytologically confirmed, previously treated (two or more lines of therapy) ES SCLC were enrolled into two cohorts. Cohort 1 received 0. Read More
J Pharm Sci 2021 Feb 27. Epub 2021 Feb 27.
Small Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.
Constrained peptides (CPs) have emerged as attractive candidates for drug discovery and development. To fully unlock the therapeutic potential of CPs, it is crucial to understand their physical stability and minimize the formation of aggregates that could induce immune responses. Although amyloid like aggregates have been researched extensively, few studies have focused on aggregates from other peptide scaffolds (e. Read More
Cell Chem Biol 2021 Feb 12. Epub 2021 Feb 12.
Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address:
The high-throughput phenotypic screen (HTPS) has become an emerging technology to discover synthetic small molecules that regulate stem cell fates. Here, we review the application of HTPS to identify small molecules controlling stem cell renewal, reprogramming, differentiation, and lineage conversion. Moreover, we discuss the use of HTPS to discover small molecules/polymers mimicking the stem cell extracellular niche. Read More