Subversion of innate immune signaling through molecular mimicry.

Authors:

J Clin Immunol 2010 Sep 30;30(5):638-42. Epub 2010 Jun 30.

Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Memorial Drive, Building 4, Room 138, Bethesda, MD 20892-0430, USA.

Innate immune signaling is mediated by a number of membrane-anchored or cytosolic receptor or sensor molecules. Several receptor families utilize conserved signaling domains such as the Toll/interleukin-1 receptor (TIR) domain and Pyrin domain (PYD) to link microbe recognition to induction of proinflammatory cytokines and interferons. Recent studies have identified a number of bacterial and viral TIR domains and PYD domains that directly target the signaling function of their host homologues. Emerging biochemical and structural studies of these microbial TIR and PYD domains suggest that they are mimics of their host counterparts at the sequence and structure levels. Unraveling the mechanisms of such molecular mimicry is crucial to our understanding and clinical intervention of infectious diseases and inflammatory disorders.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10875-010-9435-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946320PMC
September 2010
4 Reads

Publication Analysis

Top Keywords

pyd domains
8
molecular mimicry
8
immune signaling
8
innate immune
8
mimicry crucial
4
recognition induction
4
induction proinflammatory
4
biochemical structural
4
proinflammatory cytokines
4
interferons studies
4
cytokines interferons
4
unraveling mechanisms
4
mechanisms molecular
4
structural studies
4
domain pyd
4
pyrin domain
4
domain pyrin
4
domains mimics
4
pyd link
4
host counterparts
4

References

(Supplied by CrossRef)

T Kawai et al.
Int Immunol 2009

EM Palsson-McDermott et al.
Biochem Soc Trans 2007

LA O'Neill et al.
Nat Rev Immunol 2007

CA Orengo et al.
Structure 1997

HH Park et al.
Annu Rev Immunol 2007

RM Newman et al.
Infect Immun 2006

C Cirl et al.
Nat Med 2008

SP Salcedo et al.
PLoS Pathog 2008

Y Xu et al.
Nature 2000

T Nyman et al.
J Biol Chem 2008

JA Khan et al.
J Biol Chem 2004

Similar Publications