Handgrip strength: indications of paternal inheritance in three European regions.

J Gerontol A Biol Sci Med Sci 2010 Oct 28;65(10):1101-6. Epub 2010 Jun 28.

Unité Mixte de Recherche, Institut de Recherche pour le Développement, Université Montpellier 1, Montpellier, France.

Background: Handgrip strength is an indicator of overall muscle strength. Poor handgrip strength is a risk factor for disability and mortality. We aimed to investigate the pattern of inheritance of handgrip strength in a sample of parent-offspring pairs from three different European regions in Denmark, France, and Italy.

Methods: In this substudy of the European Challenge for Healthy Aging study, handgrip strength was measured in 290 subjects aged 90 years and older and in one of their offspring.

Results: When all pairs were considered together, parental and offspring handgrip strength were weakly correlated (r = .16; p < .01). However, paternal-offspring correlation was significantly higher than maternal-offspring correlation (r = .26; confidence interval [CI]: 0.11-0.41 versus r = .03; CI: -0.14 to 0.19; p = .04). This difference was particularly marked for daughters (r = -.07; CI: -0.29 to 0.16 for mother-daughter correlation versus r = .31; CI: 0.11-0.49 for father-daughter; p = .01) compared with sons (r = .12; CI: -0.13 to 0.36 for mother-son correlation versus r = .25; CI: 0.00-0.46 for father-son; p = .47). Father-daughter correlation remained higher than mother-daughter when analyses were performed with 144 nondependent parents (r = .32; CI: 0.04; 0.55 versus r = -.25; CI: -0.61 to 0.21; p = .03). These results were similarly observed in the three regions of the study, where mean levels of handgrip strength strongly differed.

Conclusions: It suggests that age-related effects on functional health among women could be mediated more through the paternal line than the maternal.

Download full-text PDF

Source
http://dx.doi.org/10.1093/gerona/glq098DOI Listing
October 2010
11 Reads

Publication Analysis

Top Keywords

handgrip strength
28
european regions
8
three european
8
correlation versus
8
handgrip
7
strength
7
correlation
5
weakly correlated
4
strength weakly
4
correlated paternal-offspring
4
055 versus
4
paternal-offspring correlation
4
correlation higher
4
confidence interval
4
parents 004
4
interval [ci]
4
correlation confidence
4
maternal-offspring correlation
4
004 055
4
higher maternal-offspring
4

References

(Supplied by CrossRef)

RANTANEN et al.
Age and Ageing 1994

Frederiksen et al.
Annals of epidemiology 2006

Rantanen et al.
Journal of Applied Physiology 1998

Giampaoli et al.
Age and Ageing 1999

Rantanen et al.
JAMA 1999

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2001

Syddall et al.
Age and Ageing 2003

Frederiksen et al.
Genetic epidemiology 2002

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2005

Rantanen et al.
Journal of the American Geriatrics Society 2003

Carmelli et al.
Journal of Applied Physiology 2000

Similar Publications