Palivizumab-resistant human respiratory syncytial virus infection in infancy.

Clin Infect Dis 2010 Jul;51(2):185-8

Institute of Virology, University Children's Hospital, Heinrich-Heine University, Düsseldorf, Germany.

Palivizumab-resistant respiratory syncytial virus was isolated from an infant treated with palivizumab. A stable mutation at codon 276 led to a nearly complete resistance to palivizumab. Additional studies revealed a second mutation at codon 272. Further passage of the virus led to a complete loss of binding of palivizumab.

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http://dx.doi.org/10.1086/653534DOI Listing
July 2010

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