Search our Database of Scientific Publications and Authors

I’m looking for a
    Cutaneous manifestations and serological findings in 260 patients with systemic lupus erythematosus.
    Lupus 2010 Sep 25;19(10):1187-94. Epub 2010 May 25.
    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Division of Dermatology, Danderyd, Sweden.
    The prevalence and prognostic value of cutaneous manifestations in patients with systemic lupus erythematosus (SLE) is not clear due to a lack of distinct criteria. Our aim was to investigate the prevalence of cutaneous manifestations in SLE patients according to strict dermatological classification, compare the results with other studies and to assess differences in serological markers between patients with and without cutaneous lupus erythematosus (CLE). Secondary aims were to investigate the validity of the criteria 'malar rash' and 'photosensitivity' for SLE diagnosis. We included 260 consecutive SLE patients, and 164 with skin complaints were examined by a dermatologist. CLE was found in 23% of the 260 SLE patients. There was agreement on the presence of malar rash in only 60% of patients seen by both rheumatologists and dermatologists. A history of polymorphous light eruption (PLE) was found in 42% of patients. Raynaud's phenomenon was significantly more common in patients with CLE. In addition, four malignant melanomas were found. Based on our findings, we suggest that the American College of Rheumatology (ACR) criteria for SLE diagnosis include histopathologically confirmed CLE as one criterion, and that the criteria photosensitivity and malar rash should be re-defined. Regular examination by a dermatologist is called for in SLE patients.

    Similar Publications

    Classification of lupus erythematosus based upon cutaneous manifestations. Dermatological, systemic and laboratory findings in 191 patients.
    Dermatology 1995 ;190(4):277-83
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
    Background: Lupus erythematosus (LE) is a multi-organ-system disease, the characteristics of which are reflected in the 1982 American Rheumatism Association (ARA) criteria for systemic lupus erythematosus (SLE). From a dermatological point of view, only the presence of LE-specific histopathology is necessary and sufficient for the diagnosis of LE. The association between the type of LE-specific skin lesion and the severity of extracutaneous manifestations of LE has not yet been investigated systematically. Read More
    Comparative analysis of subacute cutaneous lupus erythematosus and chronic cutaneous lupus erythematosus: clinical and immunological study of 270 patients.
    Br J Dermatol 2010 Jan 28;162(1):91-101. Epub 2009 Sep 28.
    Department of Dermatology, Hospital Clínic, University of Barcelona, Villarroel 170, 08036 Barcelona, Catalonia, Spain.
    Background Lupus erythematosus (LE) is a chronic, autoimmune disease resulting from an interaction of genetic, environmental and hormonal factors and characterized by a spectrum of clinical forms with variable evolution from a localized cutaneous form to a life-threatening systemic form. Objective To analyse and compare the prevalence and characteristics of the main clinical and immunological manifestations of subacute cutaneous LE (SCLE) and chronic CLE (CCLE). Methods A total of 270 patients with CLE (112 patients with SCLE and 158 patients with CCLE) were studied retrospectively. Read More
    Cutaneous manifestations of systemic lupus erythematosus.
    Br J Dermatol 1996 Sep;135(3):355-62
    Department of Dermatology, Churchill Hospital, Oxford, UK.
    We have assessed the cutaneous signs in 73 patients with systemic lupus erythematosus (SLE), seen during a 5-year period in an English hospital. Most previous information about the cutaneous manifestations of SLE has been obtained from studies performed in the U.S. Read More
    Clinical features of systemic lupus erythematosus in men. Characteristics of the cutaneous manifestations.
    Dermatology 1996 ;193(1):6-10
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
    Background: Cutaneous manifestations of systemic lupus erythematosus (SLE) in men have not been precisely investigated.

    Objective: The purpose of this study is to define the clinical features of SLE in men, focusing on skin lesions.

    Methods: The clinical and laboratory manifestations of 28 male and 111 female patients were compared. Read More