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Eur J Mass Spectrom (Chichester) 2021 Apr 7:14690667211006246. Epub 2021 Apr 7.

GVK Biosciences PVT Limited, IDA, Nacharam, Hyderabad, India.

Bortezomib (BT) is a reversible inhibitor of proteasome which is used in the treatment of hematological cancers. To study the degradation behavior, BT was subjected to acidic, basic, neutral, photolytic, oxidative and thermal degradation conditions as per ICH guideline Q1A (R2). A gradient HPLC method has been developed for separating all the degradation products formed under various degradation conditions on Waters XBridge C column (150 mm × 4. Read More

Protein J 2021 Apr 5. Epub 2021 Apr 5.

Faculty of Engineering, Düzce University, 81600, Düzce, Turkey.

A novel alanine dehydrogenase (AlaDH; EC.1.4. Read More

ACS Catal 2020 Mar 10;10(5):3313-3325. Epub 2020 Feb 10.

Graphene Labs, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy.

Metallic two-dimensional transition-metal dichalcogenides (TMDs) of the group 5 metals are emerging as catalysts for an efficient hydrogen evolution reaction (HER). The HER activity of the group 5 TMDs originates from the unsaturated chalcogen edges and the highly active surface basal planes, whereas the HER activity of the widely studied group 6 TMDs originates solely from the chalcogen- or metal-unsaturated edges. However, the batch production of such nanomaterials and their scalable processing into high-performance electrocatalysts is still challenging. Read More

Biochem Biophys Res Commun 2021 Apr 1;555:121-127. Epub 2021 Apr 1.

Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei-shi, Tokyo, 184-8588, Japan. Electronic address:

The epidermal growth factor receptor extracellular domain III (EGFR-ECDIII) protein is a promising target of anti-cancer research, and its production in Escherichia coli would thus represent significant benefits. However, despite its moderate size (19 kDa), the expression of EGFR-ECDIII in E.coli is hampered by the presence of multiple cysteines producing misfolded proteins with incorrect S-S bonds. Read More

Polymers (Basel) 2021 Mar 23;13(6). Epub 2021 Mar 23.

Polymer Chemistry Research Group, Institute of Materials and Environment Chemistry, Research Centre for Natural Sciences, Magyar tudósok körútja 2., H-1117 Budapest, Hungary.

Responsive (smart, intelligent, adaptive) polymers have been widely explored for a variety of advanced applications in recent years. The thermoresponsive poly(,-diethylacrylamide) (PDEAAm), which has a better biocompatibility than the widely investigated poly(,-isopropylacrylamide), has gained increased interest in recent years. In this paper, the successful synthesis, characterization, and bioconjugation of a novel thermoresponsive copolymer, poly(,-diethylacrylamide--glycidyl methacrylate) (P(DEAAm--GMA)), obtained by free radical copolymerization with various comonomer contents and monomer/initiator ratios are reported. Read More