G-protein-coupled receptor kinases in cardiovascular conditions: focus on G-protein-coupled receptor kinase 2, a gain in translational medicine.

Authors:
Alfonso Campanile
Alfonso Campanile
Ospedale Maggiore Policlinico
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy

Biomark Med 2009 Oct;3(5):525-40

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Sergio Pansini 5, Edificio 2, 80131 Napoli, Italy.

With increasing knowledge of the regulatory mechanisms of G-protein-coupled receptor signaling in heart physiology, many studies have focused on the role of this system in cardiovascular disease. In recent years, scientists have moved their attention from the receptors to their regulatory proteins: the G-protein-coupled receptor kinases. This class of protein is indispensable for terminating signaling of G-protein-coupled receptors through receptor desensitization and downregulation. This article attempts to assemble the currently available information regarding G-protein-coupled receptor kinases and their role in cardiovascular disease and, in particular, the potential employment of G-protein-coupled receptor kinase 2 as biomarker of cardiac dysfunction.

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm.09.50DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
October 2009
2 Reads
2.860 Impact Factor

Publication Analysis

Top Keywords

g-protein-coupled receptor
24
receptor kinases
12
receptor kinase
8
cardiovascular disease
8
g-protein-coupled
7
receptor
6
years scientists
4
focused role
4
assemble currently
4
scientists moved
4
moved attention
4
role cardiovascular
4
disease years
4
system cardiovascular
4
role system
4
attention receptors
4
currently g-protein-coupled
4
studies focused
4
kinases role
4
regulatory proteins
4

References

(Supplied by CrossRef)
Article in Nat. Rev. Mol. Cell Biol.
Pierce et al.
Nat. Rev. Mol. Cell Biol. 2002
Article in FASEB J.
Premont et al.
FASEB J. 1995
Article in Trends Pharmacol. Sci.
Willets et al.
Trends Pharmacol. Sci. 2003
Article in Cell. Signal
Metaye et al.
Cell. Signal 2005
Article in High Blood Press Cardiovasc. Prev.
Iaccarino et al.
High Blood Press Cardiovasc. Prev. 2006
Article in EMBO J.
Usui et al.
EMBO J. 2004
Article in Circulation
Ungerer et al.
Circulation 1993
Article in Circ. Res.
Cross et al.
Circ. Res. 1999

Similar Publications