ACTH protects against glucocorticoid-induced osteonecrosis of bone.

Proc Natl Acad Sci U S A 2010 May 26;107(19):8782-7. Epub 2010 Apr 26.

The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA.

We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.

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http://dx.doi.org/10.1073/pnas.0912176107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889316PMC
May 2010
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