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Determinants of Rad21 localization at the centrosome in human cells.

Authors:
Juan F Giménez-Abián Laura A Díaz-Martínez Nicole A Beauchene Wei-Shan Hsu Hung-Ji Tsai Duncan J Clarke

Cell Cycle 2010 May 15;9(9):1759-63. Epub 2010 May 15.

Department of Genetics, Cell Biology & Development, University of Minnesota Medical School, Minneapolis, MN, USA.

Cohesin proteins help maintain the physical associations between sister chromatids that arise in S-phase and are removed in anaphase. Recent studies found that cohesins also localize to the centrosomes, the organelles that organize the mitotic bipolar spindle. We find that the cohesin protein Rad21 localizes to centrosomes in a manner that is dependent upon known regulators of sister chromatid cohesion as well as regulators of centrosome function. These data suggest that Rad21 functions at the centrosome and that the regulators of Rad21 coordinate the centrosome and chromosomal functions of cohesin.

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Source
http://dx.doi.org/10.4161/cc.9.9.11523DOI Listing
May 2010

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