Targeting TLR/IL-1R signalling in human diseases.

Mediators Inflamm 2010 8;2010:674363. Epub 2010 Apr 8.

Department of Public Health and Cell Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.

The members of Toll-like receptor/interleukin (IL)-1 receptor (TLR/IL-1R) superfamily play a fundamental role in the immune response. These receptors detect microbial components and trigger complex signalling pathways that result in increased expression of multiple inflammatory genes. On the other hand, an aberrant activation of TLR/IL-1R signalling can promote the onset of inflammatory and autoimmune diseases, raising the interest in the development of therapeutic strategies for the control of their function. In this review, we illustrate the structural and functional features of TLR/IL-1R proteins and discuss some recent advances in the approaches undertaken to develop anti-inflammatory therapeutic drugs. In particular, we will focus on inhibitors, such as decoy peptides and synthetic mimetics, that interfere with protein-protein interactions between signalling molecules of the TLR/IL-1R superfamily. Given their central role in innate and adaptive immune responses, it is foreseen that pharmaceutical modulation of TLR/IL-1R signalling pathways by these drugs might yield clinical benefits in the treatment of inflammatory and autoimmune diseases.

Download full-text PDF

Source
http://www.hindawi.com/journals/mi/2010/674363/
Publisher Site
http://dx.doi.org/10.1155/2010/674363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852602PMC
July 2010
16 Reads

Publication Analysis

Top Keywords

tlr/il-1r signalling
12
autoimmune diseases
8
signalling pathways
8
inflammatory autoimmune
8
tlr/il-1r superfamily
8
tlr/il-1r
5
signalling
5
tlr/il-1r proteins
4
features tlr/il-1r
4
functional features
4
proteins discuss
4
structural functional
4
approaches undertaken
4
anti-inflammatory therapeutic
4
therapeutic drugs
4
develop anti-inflammatory
4
undertaken develop
4
advances approaches
4
discuss advances
4
review illustrate
4

Altmetric Statistics

Similar Publications