Fatal outcome of spontaneous cerebral and intraventricular hemorrhage in a child with idiopathic thrombocytopenic purpura (ITP)--case report.

Ann Acad Med Stetin 2009 ;55(1):11-3; discusison14

Klinika Pediatrii, Hematologii i Onkologui Dzieciecej Pomorskiej Akademii Medycznej w Szczecinie ul. Unii Lubelskiej 1,71-252 Szczecin

Background: Idiopathic thrombocytopenic purpura (ITP) is the most prevalent acquired hemorrhagic diathesis in children characterised by antibody-mediated destruction of platelets. ITP is generally a self-limiting benign disorder but despite this good prognosis, ITP carries the risk of severe bleeding (mainly intracranial) that may threaten the child's life.

Case Report: We describe a case of a 5-year-old girl with idiopathic thrombocytopenic purpura in the course of EBV infection with massive cerebral and intraventricular hemorrhage and fatal outcome.

Conclusion: This extremely rare case of intracranial haemorrhage in a child with ITP coexisting with EBV infection (a likely additional risk factor for hemorrhage) deserves attention considering the fatal outcome despite intensive treatment.

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May 2010
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