Higher serum uric acid associated with decreased Parkinson's disease prevalence in a large community-based survey.

Mov Disord 2010 May;25(7):932-6

Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.

A large community-based cross-sectional survey provided an opportunity to evaluate a previously reported association between Parkinson's disease (PD) and low serum uric acid (UA) levels in this population. The association between a self-reported PD diagnosis with treatment (n = 59) and serum UA level was examined using logistic and linear regression models, controlling for key covariates. In adjusted models, participants with UA levels at or above the median had a significantly lower odds of reporting PD with treatment compared with those with lower UA levels (OR 0.33, 95% CI 0.19-0.60, P = 0.0002). This association was observed for both men and women. The mean UA level among participants reporting PD with treatment was 0.78 mg/dl lower than the mean UA level among those not reporting PD (P

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http://dx.doi.org/10.1002/mds.23070DOI Listing
May 2010
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References

(Supplied by CrossRef)
Altered uric acid levels and disease states
Kutzing et al.
J Pharmacol Exp Ther 2008
Plasma urate and risk of Parkinson's disease
Weisskopf et al.
Am J Epidemiol 2007
Uric acid in Parkinson's disease
Schlesinger et al.
Mov Disord 2008
Case control study of markers of oxidative stress and metabolism of blood iron in Parkinson's disease
Larumbe Ilundain et al.
Rev Esp Salud Publica 2001

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